Violation of prophylactic vancomycin administration timing is a potential risk factor for rate of surgical site infections in cardiac surgery patients: a prospective cohort study

Table 4 Risk factors for mortality^a

	Logistic regression Univariate models			Logistic regression Multivariate model
	Odds ratio	95% CI	P	Odds ratio	95% CI	P
Age	1.13	1.07-1.19	<0.001	1.15	1.05-1.26	0.003
EuroSCORE logistic	1.24	1.17-1.31	<0.001	1.21	1.11-1.33	<0.001
Intensive care unit LOS	1.25	1.20-1.31	<0.001	1.14	1.07-1.21	<0.001
Mechanical ventilation time	1.34	1.24-1.45	<0.001	1.18	1.08-1.29	<0.001
Protocol violation^b	3.57	1.79-7.14	<0.001	10.16	2.48-41.58	<0.001

CI Confidence interval, LOS length of stay
^aDuring hospitalization or within 30 days after surgery from infectious cause
^bAntimicrobial prophylaxis timing protocol was considered as violated when the first surgical skin incision was performed before the end of the vancomycin infusion

ISSN: 1471-2261