Violation of prophylactic vancomycin administration timing is a potential risk factor for rate of surgical site infections in cardiac surgery patients: a prospective cohort study

Table 3 Risk factors for surgical site infections (SSIs)

	Logistic regression Univariate models			Logistic regression Multivariate model
	Odds ratio	95% CI	P	Odds ratio	95% CI	P
Body mass index	1.07	1.02-1.13	0.007	1.01	0.94-1.08	0.781
Internal mammary artery use	1.85	1.08-3.17	0.026	2.11	1.10-4.04	0.025
Surgical time	1.01	1.01-1.02	<0.001	1.01	1.01-1.02	<0.001
Intensive care unit LOS	1.12	1.09-1.16	<0.001	1.06	1.02-1.10	0.002
High risk^a	3.95	2.16-7.22	<0.001	4.70	2.32-9.53	<0.001
Protocol violation^b	5.93	3.15-11.17	<0.001	7.03	3.41-14.52	<0.001

CI Confidence interval, LOS length of stay
^aHigh risk of developing SSIs according to the literature [1, 8, 10]; in case of: (i) chronic liver disease (classified as Child-Pugh class B and C); (ii) insulin-dependent diabetes; (iii) body mass index <17 or >40 kg/m2; (iv) steroid or other immunosuppressive drug use; (v) chronic obstructive pulmonary disease; and (vi) extracardiac arteriopathy (i.e.,claudication, carotid occlusion or >50% stenosis, amputation for arterial disease and previous or planned intervention on the abdominal aorta, limb arteries or carotids)
^bAntimicrobial prophylaxis timing protocol was considered as violated when the first surgical skin incision was performed before the end of the vancomycin infusion

ISSN: 1471-2261