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Table 3 Clinical and histopathological findings of the 10 cases with IgG4-positive cell infiltration

From: IgG4-positive cell infiltration in various cardiovascular disorders - results from histopathological analysis of surgical samples

Case no.

Case 1

case 2

Case 3

case 4

Case 5

Case 6

Case 7

Case 8

Case 9

Case 10

Sex

male

female

female

male

female

female

female

male

female

male

Age

67

93

72

66

56

84

74

67

64

63

Cardiovascular disorder

Abdominal aortic aneurysm

Aortic dissection (type A)

Aortic dissection (type A)

Thoracic aortic aneurysm

Abdominal aortic aneurysm

Aortic stenosis

Aortic stenosis + regurgitation

Aortic stenosis + regurgitation

Aortic stenosis

Aortic stenosis

Tissue sampled

aortic wall

aortic wall

aortic wall

aortic wall

aortic wall

aortic valve

aortic valve

aortic valve

aortic valve

aortic valve

IgG4 (/HPF)

101

18.7

35

37.5

5.2

73

3

20

3

23.5

IgG4/IgG (CD138) ratio (%)

75

41.3

46.7

51.3

12.4

44.8a

8a

17.4a

30a

31.5a

Obliterating phlebitis

+

-

-

-

-

-

-

-

-

-

Storiform fibrosis

+

-

-

+

-

-

-

-

-

-

Lymphoid follicle

+

-

-

+

+

-

-

-

-

-

Eosinophil infiltration

+

-

-

-

-

-

-

-

-

-

Neutrophil infiltration

-

+

-

-

-

-

-

-

-

-

Perineural inflammation

+

-

-

-

-

-

-

-

-

-

Granuloma

-

-

-

-

-

-

-

-

-

-

Thickness of adventitial fibrosis, mm

2.4

1

2

1.2

0.1

N/A

N/A

N/A

N/A

N/A

Hemosiderin deposition

-

+

+

-

+

+

+

-

-

+

  1. N/A Not assessable
  2. aCD138 staining was performed in the place of IgG staining