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Table 6 Association between SNP genotypes and clinical characteristics of CAD patients

From: Atherosclerotic and thrombotic genetic and environmental determinants in Egyptian coronary artery disease patients: a pilot study

Gene SNP

G

Gensini score

P value

Occlusion

P value

No of BVs

P value

Low

High

<50%

≥50%

SVD

MVD

Number

14

9

8

15

8

10

FVL

N

11 (78.6)

9 (100)

0.253

7 (87.5)

13 (86.7)

1.00

7 (87.5)

9 (90)

1.00

H

3 (21.4)

0 (0.0)

1 (12.5)

2 (13.3)

 

1 (12.5)

1 (10)

FVR

N

6 (42.9)

8 (88.9)

0.040

2 (25)

12 (80)

0.023

4 (50)

9 (90)

0.118

H

8 (57.1)

1 (11.1)

6 (75)

3 (20)

4 (50)

1 (10)

F13A1

N

12 (85.7)

5 (55.6)

0.162

6 (75)

11 (73.3)

1.00

7 (87.5)

6 (60)

0.314

H

2 (14.3)

4 (44.4)

2 (25)

4 (26.7)

1 (12.5)

4 (40)

MTHFR 1

N

8 (57.1)

4 (44.4)

0.558

4 (50)

8 (53.3)

0.962

6 (75)

5 (50)

0.234

H

4 (28.6)

2 (22.2)

2 (25)

4 (26.7)

2 (25)

2 (20)

M

2 (14.3)

3 (33.3)

2 (25)

3 (20)

0 (0.0)

3 (30)

MTHFR 2

N

4 (28.6)

4 (44.4)

0.035

4 (50)

4 (26.7)

0.250

2 (25)

4 (40)

0.167

H

3 (21.5)

5 (55.6)

1 (12.5)

7 (46.7)

2 (25)

5 (50)

M

7 (50)

0 (0.0)

3 (37.5)

4 (26.7)

4 (50)

1 (10)

PAI-1

N

5 (35.7)

2 (22.2)

0.730

2 (25)

5 (33.3)

0.660

3 (37.5)

3 (30)

0.869

H

6 (42.9)

4 (44.4)

3 (37.5)

7 (46.7)

3 (37.5)

5 (50)

M

3 (21.4)

3 (33.3)

3 (37.5)

3 (20)

2 (25)

2 (20)

FGB

N

7 (50)

5 (55.6)

0.490

3 (37.5)

9 (60)

0.583

5 (62.5)

5 (50)

0.799

H

5 (35.7)

4 (44.4)

4 (50)

5 (33.3)

2 (25)

4 (40)

M

2 (14.3)

0 (0.0)

1 (12.5)

1 (6.7)

1 (12.5)

1 (10)

HPA-1

N

7 (50)

6 (66.7)

0.595

4 (50)

9 (60)

0.851

6 (75)

6 (60)

0.610

H

6 (42.9)

2 (66.7)

3 (37.5)

5 (33.3)

2 (25)

3 (30)

M

1 (7.1)

1 (22.2)

1 (12.5)

1 (6.7)

0 (0.0)

1 (10)

ACE

N

1 (7.1)

1 (11.1)

0.829

1 (12.5)

1 (6.7)

0.894

0 (0.0)

1 (10)

0.287

H

5 (35.7)

4 (44.4)

3 (37.5)

6 (40)

2 (25)

5 (50)

N

8

4 (44.4)

4 (50)

8 (53.3)

6 (75)

4 (40)

ApoE

2/2

0 (0.0)

1 (11.1)

0.492

0 (0.0)

1 (6.7)

0.658

0 (0.0)

1 (10)

0.834

2/3

2 (14.3)

1 (11.1)

1 (12.5)

2 (13.3)

1 (12.5)

1 (10)

2/4

1

0 (0.0)

1 (12.5)

0 (0.0)

0 (0.0)

0 (0.0)

3/3

10

5 (55.6)

5 (62.5)

10 (66.6)

6 (75)

7 (70)

3/4

1

2 (66.7)

1 (12.5)

2 (13.3)

1 (12.5)

1 (10)

  1. Data are presented as number (percentage). CAD coronary artery disease, SNP single nucleotide polymorphism, G genotype, N normal, H heterozygote, M mutant, No of BVs number of blood vessels, SVD single vessel disease, MVD multivessel disease, FV coagulation factor 5, MTHFR 1 and 2 Methylenetetrahydrofolate reductase (rs1801133) and (rs1801131), respectively, PAI-1 plasminogen activator inhibitor-1, FGB fibrinogen beta polypeptide chain, HPA-1 human platelet antigen 1, ACE angiotensin converting enzyme, ApoE apolipotprotein E. Fisher’s exact test was used. Bold values indicate statistically significant at p < 0.05. PTH (Prothrombin) and ApoB (Apolipoprotein B-100) gene variants were excluded from analysis as all patients were normal
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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