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Table 4 Haplotype frequencies and genotype combinations of both F5: Leiden 1691G > A with F5: R2 4070A > G, and MTHFR 667C > T with 1298A > C polymorphisms in CAD patients and controls

From: Atherosclerotic and thrombotic genetic and environmental determinants in Egyptian coronary artery disease patients: a pilot study

Haplotypesa

Overall frequency

Controls (n = 34)

Patients (n = 23)

P values

OR (95% CI)

Genotype combination: MTHFR 667C > T/1298A > C

 CC-AA

11 (19.3)

8 (23.5)

3 (13.0)

0.150

Reference

 CT-AA

3 (5.3)

2 (5.9)

1 (4.3)

 

1.3 (0.08–20.7)

 TT-AA

4 (7.0)

0 (0.0)

4 (17.4)

 

21.8 (0.9–523)

 CC-AC

9 (15.8)

6 (17.6)

3 (13)

 

1.3 (0.19–9.08)

 CT-AC

14 (24.6)

10 (29.4)

4 (17.4)

 

1.06 (0.18–6.2)

 TT–AC

1 (1.8)

0 (0.0)

1 (4.3)

 

7.2 (0.23–225)

 CC-CC

14 (24.6)

8 (23.5)

6 (26.1)

 

2.0 (0.3–10.9)

 CT-CC

1 (1.8)

0 (0.0)

1 (4.3)

 

7.2 (0.23–225)

Genotype combination: FVL 1691G > A/FVR 4070A > G

 GG-AA

41 (71.9)

28 (82.4)

13 (56.5)

0.080

Reference

 GG-AG

11 (19.3)

4 (11.8)

7 (30.4)

 

3.7 (0.9–15.18)

 GA–AA

3 (5.3)

2 (5.9)

1 (4.3)

 

1.07 (0.08–12.9)

 GA-AG

2 (3.5)

0 (0.0)

2 (8.7)

 

10.5 (0.47–235)

Block 1: MTHFR 667C > T/1298A > C

 CC

0.446

45.9

42.8

0.7437

 

 CA

0.308

36.5

22.4

0.1114

 

 TA

0.218

16.5

29.8

0.0926

 

 TC

0.027

1.1

5

0.2134

 

Block 2: FVL 1691G > A/FVR 4070A > G

 GA

0.856

91.2

77.4

0.0397

 

 GG

0.1

5.9

16.1

0.075

 

 AA

0.03

2.9

3

0.9767

 

 AG

0.014

0

3.5

0.121

 
  1. MTHFR, Methylenetetrahydrofolate reductase; FV, coagulation factor 5
  2. aHaploview version 4.1 was used for data analysis. Bold values indicate statistically significant at p < 0.05