Table 3 Genotype and allele frequencies of atherosclerotic gene variants in the study population

FGB

Normal

22 (64.7)

12 (52.2)

0.636

1.0

1.0

-455G > A

Hetero

10 (29.4)

9 (39.1)

1.6 (0.5–5.2)

0.28 (0.02–3.1)

Homo

2 (5.9)

2 (8.7)

1.8 (0.2–14.7)

1.65 (0.1–20.2)

Dominant model

12 (35.3)

11 (47.8)

1.6 (0.5–4.9)

p HWE

0.557

0.866

MAF (A)

0.21

0.28

0.344

1.5 (0.6–3.6)

HPA-1

a/a

26 (76.5)

13 (56.5)

0.112

1.0

1.0

a/b

a/b

8 (23.5)

8 (34.8)

2.0 (0.6–6.5)

b/b

0 (0.0)

2 (8.7)

9.8 (0.4–21.9)

4.0 (1.4–6.4)

Dominant model

8 (23.5)

10 (43.5)

2.5 (0.7–7.8)

p HWE

0.436

0.638

MAF (b)

0.12

0.26

0.048

2.6 (0.9–7.1)

ACE

I/I

6 (17.6)

2 (8.7)

<0.001

1.0

1.0

I/D

I/D

26 (76.5)

9 (39.1)

1.0 (0.1–6.1)

2.79 (0.3–29.7)

D/D

2 (5.9)

12 (52.2)

18 (2.0–161)

88.3 (4.3–179)

Dominant model

28 (82.4)

21 (91.3)

2.3 (0.4–12.2)

p HWE

0.001

0.866

MAF (D)

0.44

0.72

0.003

3.2 (1.4–7.1)

ApoB

Normal

34 (100)

23 (100)

NA

NA

R3500Q

p HWE

NA

NA

ApoE

E2/E2

0 (0.0)

1 (4.3)

0.009

1.0

E2/E3/E4

E2/E4

2 (5.9)

1 (4.3)

0.2 (0.0–8.8)

E2/E3

20 (58.8)

3 (13.0)

0.05 (0.0–1.6)

E3/E3

10 (29.4)

15 (65.2)

0.4 (0.01–13.2)

E3/E4

2 (5.9)

3 (13.0)

0.4 (0.01–16.8)

p HWE^a

0.060

0.550

E3

0.61

0.78

0.004

1.0

E2

0.32

0.13

0.08 (0.04–0.18)

E4 (MAF)

0.06

0.09

0.61 (0.2–1.87)