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Table 4 Cox proportional hazard model of baseline biochemical risk factors for the development of major adverse cardiovascular events stratified by acute coronary syndrome and elective PCI subjects

From: The burden of major adverse cardiac events in patients with coronary artery disease

 

Acute coronary syndrome

Elective PCI

Baseline data

Univariate analysis

HR (95% CI)

P value

Multivariate model HR (95% CI)

P-value

Univariate analysis

HR (95% CI)

P value

Multivariate model HR (95% CI)

P value

Body mass index

0.98 (0.95–1.01)

0.135

  

0.99 (0.97–1.03)

0.942

  

Waist circumference

1.01 (0.99–1.02)

0.131

  

1.01 (0.99–1.02)

0.172

  

Waist to hip ratio

3.45 (1.30–7.40)

0.016

  

3.56 (1.29–7.03)

0.019

  

Systolic BP

0.99 (0.99–1.00)

0.701

  

1.01 (0.99–1.01)

0.146

  

Diastolic BP

0.24 (0.07–0.90)

0.034

  

0.15 (0.02–0.97)

0.046

  

HbA1C

1.06 (0.99–1.11)

0.063

  

1.06 (0.99–1.16)

0.192

  

Fasting glucose

3.98 (2.24–6.98)

<0.0001

  

3.82 (1.85–7.66)

0.0004

  

Total cholesterol

0.43 (0.24–0.91)

0.030

  

1.04 (0.30–3.61)

0.946

  

Triglyceride

0.99 (0.99–1.00)

0.121

  

0.99 (0.99–1.00)

0.154

  

HDL-cholesterol

0.29 (0.11–0.77)

0.014

  

0.30 (0.11–0.83)

0.021

  

LDL-cholesterol

1.00 (0.99–1.00)

0.447

  

1.00 (0.99–1.01)

0.221

  

Uric acid

1.00 (0.96–1.03)

0.981

  

1.17 (1.09–1.26)

<0.0001

1.14 (1.01–1.28)

0.041

Creatinine

1.10 (1.03–1.16)

0.005

  

1.09 (1.05–1.13)

0.0004

  

eGFR

0.46 (0.32–0.66)

0.0001

0.20 (0.05–0.86)

0.031

0.32 (0.23–0.48)

<0.0001

  

Hs–CRP

1.00 (0.99–1.01)

0.713

  

1.01 (1.00–1.01)

0.013

  

White blood cell

1.02 (0.99–1.05)

0.148

  

1.01 (0.97–1.05)

0.653

  

Red blood cell

0.84 (0.73–0.97)

0.017

  

0.88 (0.73–1.04)

0.158

  

Hemoglobin

0.93 (0.89–0.98)

0.004

  

0.95 (0.89–1.02)

0.143

  

Hematocrit

0.98 (0.96–0.99)

0.003

  

0.98 (0.95–1.00)

0.073

  

MCV

1.00 (0.98–1.01)

0.656

  

1.02 (1.00–1.04)

0.047

  

MCH

0.97 (0.94–1.01)

0.099

  

1.00 (0.97–1.01)

0.687

  

MCHC

0.91 (0.84–0.99)

0.029

  

0.89 (0.81–0.98)

0.016

  
  1. PCI, percutaneous coronary intervention; HR, hazard ratio; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular-hemoglobin concentration. eGFR = estimated glomerular filtration rate calculated by the chronic kidney disease-EPI two-level race equation [12]