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Table 4 Relative risk of cardiovascular disease, according to increases in fish/seafood consumption from baseline to third year of follow-up and baseline toenail mercury, among case participants and matched controls in the PREDIMED trial

From: Mercury exposure and risk of cardiovascular disease: a nested case-control study in the PREDIMED (PREvention with MEDiterranean Diet) study

  Increase in Fish/seafood consumption & baseline toenail Mercury
Low Hg/No increase in fish Low Hg/Increased Fish High Hg/No increase in fish High Hg/Increased Fish
Mean mercury (μg/g) 0.33 (0.11) 0.33 (0.10) 0.99 (0.59) 0.84 (0.26)
% with high fish in MeDiet score 52 100 67 100
Total sample
 Cases/matched controls 62/87 16/38 54/116 14/30
 Matched ORa (95% CI) 1 (ref.) 0.46 (0.21, 1.01) 0.62 (0.38, 1.03) 0.48 (0.20, 1.15)
 Matched ORb (95% CI) 1 (ref.) 0.52 (0.23, 1.17) 0.65 (0.38, 1.12) 0.52 (0.20–1.34)
 Matched ORc (95% CI) 1 (ref.) 0.50 (0.21, 1.18) 0.66 (0.37, 1.16) 0.54 (0.20, 1.44)
  1. aModels are from conditional logistic regression analyses with matching factors sex and age and adjusted for PREDIMED center
  2. bAdditionally djusted for month of toenail collection, smoking, hypertension, hypercholestaerolemia, diabetes and family history of premature coronary heart disease
  3. cAdditionally adjusted for intervention group, total energy intake, body mass index, physical activity (quartiles), alcohol intake (<5/10 gr, moderate consumption, >25/50 g in women/men) and non-fish consumption of n-3 fatty acids (continuous g/d)