Mercury exposure and risk of cardiovascular disease: a nested case-control study in the PREDIMED (PREvention with MEDiterranean Diet) study

Table 3 Relative risk of cardiovascular disease, according to baseline toenail mercury and fish/seafood consumption, among case participants and matched controls in the PREDIMED trial

	Baseline toenail Mercury and fish/seafood consumption
	Low Hg/Low Fish	Low Hg/High Fish	High Hg/Low Fish	High/High
Mean mercury (μg/g)	0.31 (0.12)	0.36 (0.09)	0.92 (0.52)	0.99 (0.56)
Fish/seafood consumption (g/d)	62 (39)	119 (39.4)	75 (36)	115 (35)
Total sample
Cases/matched controls	41/73	37/52	29/58	39/88
Matched OR^a (95% CI)	1 (ref.)	1.09 (0.56, 2.11)	0.66 (0.33, 1.31)	0.85 (0.48, 1.50)
Matched OR^b (95% CI)	1 (ref.)	1.08 (0.53, 2.19)	0.68 (0.32, 1.44)	0.85 (0.46, 1.55)
Matched OR^c (95% CI)	1 (ref.)	1.18 (0.51, 2.77)	0.73 (0.34, 1.59)	0.91 (0.43, 1.93)

^aModels are from conditional logistic regression analyses with matching factors sex and age and adjusted for PREDIMED center
^bAdditionally adjusted for month of toenail collection, smoking, hypertension, hypercholestaerolemia, diabetes and family history of premature coronary heart disease
^cAdditionally adjusted for intervention group, total energy intake, body mass index, physical activity (quartiles), alcohol intake (<5/10 gr, consumption, >25/50 g in women/men) and non-fish consumption of n-3 fatty acids (continuous g/d)

ISSN: 1471-2261