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Table 3 Relative risk of cardiovascular disease, according to baseline toenail mercury and fish/seafood consumption, among case participants and matched controls in the PREDIMED trial

From: Mercury exposure and risk of cardiovascular disease: a nested case-control study in the PREDIMED (PREvention with MEDiterranean Diet) study

  Baseline toenail Mercury and fish/seafood consumption
Low Hg/Low Fish Low Hg/High Fish High Hg/Low Fish High/High
Mean mercury (μg/g) 0.31 (0.12) 0.36 (0.09) 0.92 (0.52) 0.99 (0.56)
Fish/seafood consumption (g/d) 62 (39) 119 (39.4) 75 (36) 115 (35)
Total sample
 Cases/matched controls 41/73 37/52 29/58 39/88
 Matched ORa (95% CI) 1 (ref.) 1.09 (0.56, 2.11) 0.66 (0.33, 1.31) 0.85 (0.48, 1.50)
 Matched ORb (95% CI) 1 (ref.) 1.08 (0.53, 2.19) 0.68 (0.32, 1.44) 0.85 (0.46, 1.55)
 Matched ORc (95% CI) 1 (ref.) 1.18 (0.51, 2.77) 0.73 (0.34, 1.59) 0.91 (0.43, 1.93)
  1. aModels are from conditional logistic regression analyses with matching factors sex and age and adjusted for PREDIMED center
  2. bAdditionally adjusted for month of toenail collection, smoking, hypertension, hypercholestaerolemia, diabetes and family history of premature coronary heart disease
  3. cAdditionally adjusted for intervention group, total energy intake, body mass index, physical activity (quartiles), alcohol intake (<5/10 gr, consumption, >25/50 g in women/men) and non-fish consumption of n-3 fatty acids (continuous g/d)