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Table 2 Relative risk of cardiovascular disease, according to quartiles of toenail mercury, among case participants and matched controls in the PREDIMED trial

From: Mercury exposure and risk of cardiovascular disease: a nested case-control study in the PREDIMED (PREvention with MEDiterranean Diet) study

Variable   Sex-specific quartiles of toenail mercury  
  number of cases Q1 Q2 Q3 Q4 p for trend
Mean mercury (μg/g)   0.25 (0.08) 0.43 (0.05) 0.65 (0.10) 1.30 (0.62)  
Total samplea
 Cases/matched controls 147/267 44/60 39/66 33/72 31/69  
 Matched OR (95% CI)   1 (ref.) 0.93 (0.51, 1.70) 0.76 (0.42, 1.39) 0.60 (0.32, 1.13) 0.09
 Matched ORb (95% CI)   1 (ref.) 0.91 (0.48, 1.71) 0.84 (0.44, 1.59) 0.56 (0.28, 1.12) 0.09
 Matched ORc (95% CI)   1 (ref.) 0.86 (0.43, 1.72) 0.85 (0.43, 1.72) 0.66 (0.31, 1.41) 0.11
Mediterranean diet interventiond
 Cases/controls 91/197 23/39 25/49 20/55 23/54  
 Adjusted OR (95% CI)   1 (ref.) 0.99 (0.46–2.12) 0.66 (0.30, 1.46) 0.72 (0.33, 1.55) 0.32
 Adjusted ORe (95% CI)   1 (ref.) 0.96 (0.43–2.14) 0.71 (0.30, 1.64) 0.66 (0.29–1.49) 0.27
 Adjusted ORf (95% CI)   1 (ref.) 1.00 (0.43, 2.32) 0.68 (0.28, 1.63) 0.74 (0.31, 1.75) 0.67
Control (low-fat) groupd
 Cases/controls 56/74 21/22 14/17 13/18 8/18  
 Adjusted OR (95% CI)   1 (ref.) 0.97 (0.35, 2.64) 0.78 (0.28, 2.17) 0.40 (0.12, 1.34) 0.13
 Adjusted ORe (95% CI)   1 (ref.) 1.08 (0.36, 3.23) 0.99 (0.33, 2.98) 0.44 (0.12, 1.64) 0.25
 Adjusted ORf (95% CI)   1 (ref.) 1.11 (0.34, 3.64) 1.06 (0.34, 3.38) 0.63 (0.15, 2.61) 0.75
  1. aModels are from conditional logistic regression analyses with matching factors sex and age and adjusted for PREDIMED center
  2. bAdditionally adjusted for age, month of toenail collection, smoking, hypertension, hypercholestaerolemia, diabetes and family history of premature coronary heart disease
  3. cAdditionally adjusted for intervention group, baseline adherence to the Mediterranean diet, body mass index, physical activity (quartiles), alcohol intake (<5/10 gr, moderate consumption, >25/50 g in women/men), fish intake (continuous g/d) and non-fish consumption of n-3 fatty acids (continuous g/d)
  4. dModels are from multivariate-adjusted logistic regression, adjusted for sex, age and PREDIMED center
  5. eAdditionally adjusted for month of toenail collection, smoking, hypertension, hypercholestaerolemia, diabetes and family history of premature coronary heart disease
  6. fAdditionally adjusted for intervention group, baseline adherence to the Mediterranean diet, body mass index, physical activity (quartiles), alcohol intake (<5/10 gr, moderate consumption, >25/50 g in women/men), fish intake (continuous g/d) and non-fish consumption of n-3 fatty acids (continuous g/d)