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Table 5 Adjusted hazard ratios (and 95% CI) for an increase of 0.1 mmol/L in uric acid overall and by history of gout in the full cohort from an extended Model 2 that includes interaction between history of gout and uric acid level

From: Asymptomatic hyperuricemia is not an independent risk factor for cardiovascular events or overall mortality in the general population of the Busselton Health Study

CVE history = no

CVE history = yes

Overall

(n = 3,475)

Gout = yes

(n = 49)

Gout = no

(n = 3,426)

p-value

Overall

(n = 698)

Gout = yes

(n = 25)

Gout = no

(n = 673)

p-value

All-cause mortality

1.15 (0.98,1.35)

1.65 (0.90,3.03)

1.13 (0.96,1.33)

0.224

 

1.28 (0.76,2.15)

0.91 (0.75,1.11)

0.214

Cardiovascular mortality

1.17 (0.91,1.52)

1.77 (0.67,4.69)

1.16 (0.89,1.51)

0.400

 

2.13 (1.03,4.43)

0.94 (0.70,1.24)

0.038

Cardiovascular event

1.09 (0.94,1.26)

1.28 (0.64,2.56)

1.08 (0.93,1.26)

0.638

 

1.41 (0.91,2.18)

0.95 (0.79,1.13)

0.089

  1. HR is adjusted for sex, age (and age squared), smoking status, BMI, SBP, hypertension meds, cholesterol, HDL cholesterol, ln(triglycerides), lipid meds, diuretic use, ln(CRP) and eGFR
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