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Table 3 Association between UA level and all-cause mortality, CVE mortality and CVE event in the subcohort with multiple UA measures and without history of CVE at baseline

From: Asymptomatic hyperuricemia is not an independent risk factor for cardiovascular events or overall mortality in the general population of the Busselton Health Study

UA measure Model 1a Model 2a
HR (95% CI) p-value HR (95% CI) p-value
All-cause mortality
 UAb 1.17 (1.01,1.36) 0.031 1.17 (0.98,1.40) 0.082
 UA z-scoreb 1.13 (1.00,1.27) 0.040 1.13 (0.98,1.30) 0.097
 UA category   0.636   0.906
  Low 1.00   1.00  
  Medium 1.07 (0.83,1.36) 0.609 1.03 (0.79,1.34) 0.833
  High 1.18 (0.84,1.67) 0.343 1.09 (0.73,1.64) 0.658
 Average UA z-scoreb 1.18 (1.02,1.36) 0.027 1.18 (1.00,1.39) 0.046
 Annual change UA z-scorec 1.14 (0.92,1.41) 0.220 1.11 (0.88,1.39) 0.379
Cardiovascular mortality
 UAb 1.18 (0.94,1.49) 0.152 1.10 (0.83,1.47) 0.507
 UA z-scoreb 1.14 (0.94,1.37) 0.173 1.07 (0.85,1.35) 0.544
 UA category   0.838   0.977
  Low 1.00   1.00  
  Medium 1.11 (0.75,1.63) 0.603 0.96 (0.63,1.46) 0.841
  High 1.15 (0.66,2.00) 0.622 0.98 (0.51,1.89) 0.962
 Average UA z-scoreb 1.18 (0.93,1.49) 0.172 1.15 (0.88,1.49) 0.303
 Annual change UA z-scorec 1.21 (0.89,1.64) 0.219 1.10 (0.79,1.54) 0.573
Cardiovascular event
 UAb 1.25 (1.09,1.44) 0.001 1.09 (0.92,1.30) 0.300
 UA z-scoreb 1.17 (1.05,1.31) 0.004 1.05 (0.92,1.20) 0.446
 UA category   0.032   0.848
  Low 1.00   1.00  
  Medium 1.28 (1.01,1.63) 0.042 1.08 (0.83,1.40) 0.576
  High 1.52 (1.08,2.14) 0.015 1.09 (0.73,1.62) 0.668
 Average UA z-scoreb 1.15 (1.00,1.31) 0.053 1.03 (0.88,1.20) 0.746
 Annual change UA z-scorec 1.31 (1.05,1.64) 0.017 1.11 (0.88,1.41) 0.384
  1. Table shows hazard ratio, 95% CI and p-value from Cox regression models
  2. aModel 1 is adjusted for sex and age (and age squared). Model 2 is further adjusted for smoking status, BMI, SBP, hypertension meds, cholesterol, HDL cholesterol, ln(triglycerides), lipid meds, diuretic use, ln(CRP) and eGFR
  3. bHR is presented for a change of 0.1 mmol/L for UA and for a change of 1.0 for UA Z-score and average UA z-score
  4. cHR is presented for a change of 0.1 for annual change in UA Z-score. HR comes from model that also includes average UA z-score