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Table 2 Association between UA level and all-cause mortality, CVE mortality and CVE event in the full cohort without a history of CVE at baseline

From: Asymptomatic hyperuricemia is not an independent risk factor for cardiovascular events or overall mortality in the general population of the Busselton Health Study

UA measure Model 1a Model 2a
HR (95% CI) p-value HR (95% CI) p-value
All-cause mortality
 UAb 1.19 (1.04,1.36) 0.010 1.15 (0.98,1.35) 0.089
 UA z-scoreb 1.15 (1.03,1.27) 0.009 1.12 (0.99,1.27) 0.069
 UA category   0.210   0.666
  Low 1.00   1.00  
  Medium 1.07 (0.86,1.33) 0.553 1.01 (0.79,1.28) 0.939
  High 1.31 (0.97,1.79) 0.080 1.15 (0.81,1.65) 0.428
Cardiovascular mortality
 UAb 1.27 (1.03,1.57) 0.025 1.17 (0.91,1.52) 0.225
 UA z-scoreb 1.21 (1.02,1.43) 0.025 1.14 (0.93,1.40) 0.212
 UA category   0.539   0.974
  Low 1.00   1.00  
  Medium 1.16 (0.81,1.67) 0.411 0.99 (0.67,1.47) 0.964
  High 1.30 (0.79,2.15) 0.295 1.05 (0.58,1.90) 0.872
Cardiovascular event
 UAb 1.28 (1.13,1.44) <0.001 1.09 (0.94,1.26) 0.267
 UA z-scoreb 1.19 (1.08,1.31) <0.001 1.05 (0.94,1.18) 0.377
 UA category   0.016   0.985
  Low 1.00   1.00  
  Medium 1.23 (1.00,1.52) 0.049 1.02 (0.81,1.28) 0.877
  High 1.52 (1.13,2.04) 0.005 1.03 (0.73,1.44) 0.883
  1. Table shows hazard ratio, 95% CI and p-value from Cox regression models
  2. aModel 1 is adjusted for sex and age (and age squared). Model 2 is further adjusted for smoking status, BMI, SBP, hypertension meds, cholesterol, HDL cholesterol, ln(triglycerides), lipid meds, diuretic use, ln(CRP) and eGFR
  3. bHR is presented for a change of 0.1 mmol/L for UA and for a change of 1.0 for UA Z-score