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Table 2 Association between UA level and all-cause mortality, CVE mortality and CVE event in the full cohort without a history of CVE at baseline

From: Asymptomatic hyperuricemia is not an independent risk factor for cardiovascular events or overall mortality in the general population of the Busselton Health Study

UA measure

Model 1a

Model 2a

HR (95% CI)

p-value

HR (95% CI)

p-value

All-cause mortality

 UAb

1.19 (1.04,1.36)

0.010

1.15 (0.98,1.35)

0.089

 UA z-scoreb

1.15 (1.03,1.27)

0.009

1.12 (0.99,1.27)

0.069

 UA category

 

0.210

 

0.666

  Low

1.00

 

1.00

 

  Medium

1.07 (0.86,1.33)

0.553

1.01 (0.79,1.28)

0.939

  High

1.31 (0.97,1.79)

0.080

1.15 (0.81,1.65)

0.428

Cardiovascular mortality

 UAb

1.27 (1.03,1.57)

0.025

1.17 (0.91,1.52)

0.225

 UA z-scoreb

1.21 (1.02,1.43)

0.025

1.14 (0.93,1.40)

0.212

 UA category

 

0.539

 

0.974

  Low

1.00

 

1.00

 

  Medium

1.16 (0.81,1.67)

0.411

0.99 (0.67,1.47)

0.964

  High

1.30 (0.79,2.15)

0.295

1.05 (0.58,1.90)

0.872

Cardiovascular event

 UAb

1.28 (1.13,1.44)

<0.001

1.09 (0.94,1.26)

0.267

 UA z-scoreb

1.19 (1.08,1.31)

<0.001

1.05 (0.94,1.18)

0.377

 UA category

 

0.016

 

0.985

  Low

1.00

 

1.00

 

  Medium

1.23 (1.00,1.52)

0.049

1.02 (0.81,1.28)

0.877

  High

1.52 (1.13,2.04)

0.005

1.03 (0.73,1.44)

0.883

  1. Table shows hazard ratio, 95% CI and p-value from Cox regression models
  2. aModel 1 is adjusted for sex and age (and age squared). Model 2 is further adjusted for smoking status, BMI, SBP, hypertension meds, cholesterol, HDL cholesterol, ln(triglycerides), lipid meds, diuretic use, ln(CRP) and eGFR
  3. bHR is presented for a change of 0.1 mmol/L for UA and for a change of 1.0 for UA Z-score