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Table 5 Association of the VEGFA genotype with the Gensini score after adjustment for clinical variables

From: The association of functional polymorphisms in genes encoding growth factors for endothelial cells and smooth muscle cells with the severity of coronary artery disease

Gene /polymorphism

Dominant Model* (mean Gensini score ± standard error)

P

Recessive Model* (mean Gensini score ± standard error)

P

Log additive model*

P

 

Genotypes

 

Genotype

 

Difference in Gensini score per minor allele (95 % CI)

 
 

A/A (ref.)

A/C + C/C

 

A/A + A/C (ref.)

C/C

 

Per C allele

 
 

Whole cohort

VEGFA

rs699947

37.9 ± 3.2

35.6 ± 1.9

0.57

37.9 ± 2.0

31.6 ± 2.7

0.22

−2.3 (−6.4 ÷ 1.9)

0.28

 

Patients without previous myocardial infarction

VEGFA

rs699947

26.4 ± 2.4

35.1 ± 2.1

0.04

31.4 ± 2.0

35.5 ± 3.3

0.41

3.8 (−0.51 ÷ 8.0)

0.09

  1. *The models were adjusted for: age, sex, hypertension, atrial fibrillation, diabetes mellitus, previous myocardial infarction and creatinine
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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