|
NPR on aspirin (n = 1240)
|
HPR on aspirin (n = 91)
|
P value
|
NPR on clopidogrel (n = 891)
|
HPR on clopidogrel (n = 437)
|
P value
|
---|
In hospital
|
Definite/probable Stent thrombosis
|
1
|
0
|
NS
|
0
|
1
|
0.329
|
All cause death
|
0
|
0
|
NS
|
0
|
0
|
NS
|
Cardiac death
|
0
|
0
|
NS
|
0
|
0
|
NS
|
Spontaneous MI
|
2
|
0
|
NS
|
0
|
2
|
0.108
|
TLR
|
1
|
0
|
NS
|
0
|
1
|
0.329
|
TVR
|
1
|
0
|
NS
|
0
|
1
|
0.329
|
Ischemic stroke
|
8 (0.6)
|
0
|
NS
|
4 (0.4)
|
4 (0.9)
|
0.451
|
All bleeding
|
39 (3.1)
|
3 (3.3)
|
0.762
|
30 (3.4)
|
12 (2.7)
|
0.619
|
Hemorrhagic stroke
|
3 (0.2)
|
0
|
NS
|
3 (0.3)
|
0
|
0.555
|
MACCE
|
10 (0.8)
|
0
|
NS
|
4 (0.5)
|
6 (1.4)
|
0.090
|
At 1 years
|
Definite/probable Stent thrombosis
|
3 (0.2)
|
8 (8.8)
|
< 0.001
|
1 (0.1)
|
10 (2.3)
|
< 0.001
|
All cause death
|
8 (0.6)
|
2 (2.2)
|
0.146
|
3 (0.3)
|
7 (1.6)
|
0.018
|
Cardiac death
|
2 (0.2)
|
2 (2.2)
|
0.025
|
1 (0.1)
|
3 (0.7)
|
0.107
|
Spontaneous MI
|
17 (1.4)
|
3 (3.3)
|
0.152
|
10 (1.1)
|
10 (2.3)
|
0.147
|
TLR
|
30 (2.4)
|
0 (0)
|
0.260
|
25 (2.8)
|
5 (1.1)
|
0.075
|
TVR
|
31 (2.5)
|
0 (0)
|
0.265
|
25 (2.8)
|
6 (1.4)
|
0.123
|
Ischemic stroke
|
9 (0.7)
|
1 (1.1)
|
0.509
|
9 (1.0)
|
1 (0.2)
|
0.180
|
All bleeding
|
64 (5.2)
|
3 (3.3)
|
0.619
|
48 (5.4)
|
19 (4.3)
|
0.505
|
Hemorrhagic stroke
|
5 (0.4)
|
0
|
NS
|
3 (0.3)
|
2 (0.5)
|
0.666
|
MACCE
|
40 (3.2)
|
5 (5.5)
|
0.228
|
30 (3.4)
|
15 (3.4)
|
0.951
|
At 2 years
|
Definite/probable Stent thrombosis
|
5 (0.4)
|
9 (9.9)
|
< 0.001
|
1 (0.1)
|
13 (3.0)
|
< 0.001
|
All cause death
|
20 (1.6)
|
7 (7.7)
|
0.002
|
3 (0.3)
|
23 (5.3)
|
< 0.001
|
Cardiac death
|
4 (0.3)
|
7 (7.7)
|
< 0.001
|
1 (0.1)
|
10 (2.3)
|
< 0.001
|
Spontaneous MI
|
23 (1.9)
|
9 (9.9)
|
< 0.001
|
11 (1.2)
|
21 (4.8)
|
< 0.001
|
TLR
|
60 (4.8)
|
5 (5.5)
|
0.799
|
51 (5.7)
|
14 (3.2)
|
0.057
|
TVR
|
65 (5.2)
|
5 (5.5)
|
0.809
|
51 (5.7)
|
19 (4.3)
|
0.360
|
Ischemic stroke
|
16 (1.3)
|
2 (2.2)
|
0.352
|
12 (1.3)
|
6 (1.4)
|
NS
|
All bleeding
|
118 (10.0)
|
8 (9.2)
|
NS
|
93 (10.9)
|
33 (7.9)
|
0.110
|
Hemorrhagic stroke
|
8 (0.6)
|
0 (0)
|
NS
|
4 (0.4)
|
4 (0.9)
|
0.451
|
MACCE
|
106 (8.5)
|
15 (16.5)
|
0.021
|
66 (7.4)
|
54 (12.4)
|
0.004
|
- MI myocardial infarction, TLR target lesion revascularization, TVR target vessel revascularization, MACCE adverse cardiovascular and cerebrovascular events, NPR normal platelet reactivity, HPR high platelet reactivity