| |
NPR on aspirin (n = 1240)
|
HPR on aspirin (n = 91)
|
P value
|
NPR on clopidogrel (n = 891)
|
HPR on clopidogrel (n = 437)
|
P value
|
|---|
|
Age, yrs
|
64.19 ± 10.06
|
65.63 ± 9.75
|
0.189
|
63.96 ± 10.23
|
64.98 ± 9.60
|
0.082
|
|
Male, n (%)
|
936 (75.5)
|
67 (73.6)
|
0.706
|
692 (77.7)
|
310 (70.9)
|
0.008
|
|
BMI, kg/mm2
|
24.70 ± 3.01
|
24.55 ± 3.01
|
0.649
|
24.65 ± 2.95
|
24.78 ± 3.12
|
0.449
|
|
Hypertension, n (%)
|
888 (71.6)
|
66 (72.5)
|
0.905
|
644 (72.3)
|
307 (70.3)
|
0.438
|
|
Hyperlipidemia, n (%)
|
318 (27.4)
|
23 (25.6)
|
0.806
|
236 (28.3)
|
105 (25.4)
|
0.281
|
|
Diabetes, n (%)
|
328 (26.5)
|
24 (26.4)
|
NS
|
239 (26.8)
|
112 (25.6)
|
0.691
|
|
Current smoking, n (%)
|
482 (39.2)
|
33 (36.7)
|
0.656
|
356 (40.3)
|
159 (36.7)
|
0.229
|
|
ACS, n (%)
|
1072 (86.5)
|
75 (82.4)
|
0.272
|
782 (87.8)
|
362 (82.8)
|
0.018
|
|
eGFR < 60 ml/min/1.73 m2, n (%)
|
122 (10.1)
|
8 (9.2)
|
NS
|
94 (10.9)
|
36 (8.4)
|
0.170
|
|
Prior stroke, n (%)
|
138 (11.2)
|
11 (12.2)
|
0.731
|
93 (10.5)
|
56 (12.9)
|
0.196
|
|
Prior PCI, n (%)
|
236 (19.2)
|
15 (16.7)
|
0.676
|
161 (18.2)
|
89 (20.6)
|
0.331
|
|
LVEF, %
|
59.80 ± 9.33
|
58.50 ± 9.89
|
0.275
|
59.59 ± 9.27
|
59.94 ± 9.61
|
0.587
|
|
hsCRP, ug/ml
|
31.94 ± 8.88
|
32.84 ± 9.16
|
0.400
|
31.98 ± 8.80
|
32.13 ± 9.11
|
0.804
|
|
Agents in hospital
|
|
Aspirin, 100 mg/d
|
1216 (98.1)
|
90 (98.9)
|
NS
|
881 (98.9)
|
428 (97.9)
|
0.218
|
|
Clopidogrel, 75 mg/d
|
1203 (97.0)
|
88 (96.7)
|
0.751
|
863 (96.9)
|
426 (97.5)
|
0.606
|
|
Agents at 2 years
|
|
Aspirin (100 mg/d), n (%)
|
1142 (92.1)
|
81 (89.0)
|
0.317
|
800 (89.8)
|
398 (91.1)
|
0.493
|
|
Clopidogrel (75 mg/d), n (%)
|
806 (65.0)
|
57 (62.6)
|
0.650
|
570 (64.0)
|
266 (61.9)
|
0.277
|
- BMI body mass index, ACS acute coronary syndrome, eGFR estimated glomerular filtration rate, PCI percutaneous coronary intervention, LVEF left ventricular ejection fraction, hsCRP high sensitivity C reactive protein, NPR normal platelet reactivity, HPR high platelet reactivity
