Changes in selected metabolic parameters in patients over 65 receiving hydrochlorothiazide plus amiloride, atenolol or placebo in the MRC elderly trial

Table 3 Mean (SE of mean) within-patient changes over time by treatment group

Changes	Potassium	Sodium	Glucose	Cholesterol	Weight	Urea	Urate
Changes	Mean changes (SE)	Mean changes (SE)	Mean changes (SE)	Mean changes (SE)	Mean changes (SE)	Mean changes (SE)	Mean changes (SE)
Placebo
Yr1 vs. Yr0	−0.00 (0.01)	−0.19 (0.05)**	−0.00 (0.02)	−0.03 (0.02)	−0.45 (0.08)**	0.08 (0.03)**	3.35 (1.09)**
Yr2 vs. Yr1	0.02 (0.1)**	−0.00 (0.05)	0.05 (0.02)**	0.07 (0.02)**	−0.23 (0.07)**	0.16 (0.03)**	3.89 (1.17)**
Hydrochlorothiazide + amiloride
Yr1 vs. Yr0	−0.18 (0.01)^,*	−1.64 (0.07)^,*	0.03 (0.03)	0.13 (0.02)^,*	−0.91 (0.11)^,*	0.85 (0.04)^,*	56.45 (1.57)^,*
Yr2 vs. Yr1	0.04 (0.04)**	0.14 (0.08)	0.04 (0.03)	−0.01 (0.03)*	−0.26 (0.11)**	0.13 (0.05)**	−3.21 (1.67)*
Atenolol
Yr1 vs. Yr0	0.07 (0.01)^,*	−0.78 (0.07)^,*	−0.01 (0.03)	0.04 (0.02)*	0.05 (0.11)*	0.62 (0.04)^,*	43.00 (1.55)^,*
Yr2 vs. Yr1	−0.03 (0.01)*	−0.14 (0.08)	0.03 (0.03)	0.08 (0.03)**	−0.03 (0.11)	0.21 (0.05)**	4.81 (1.68)**

*Indicates P <0.05 and refers to test for difference in change in active treatment group compared to placebo group
**Indicates P <0.05 and refers to within-patient changes over time in each group

ISSN: 1471-2261