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Table 1 Changes in the hemodynamic parameters in three groups

From: Pulmonary artery denervation improves pulmonary arterial hypertension induced right ventricular dysfunction by modulating the local renin-angiotensin-aldosterone system

  Control (n = 6) Sham (n = 6) PADN (n = 7)
Heart beats/min
Week 0
Week 8
Week 14
147.71 ± 25.09
138.57 ± 22.87
134.43 ± 37.95
160.00 ± 17.06
157.70 ± 22.26
159.60 ± 23.81
158.67 ± 13.37
165.89 ± 10.75
159.67 ± 10.14
PVR, Wood units
Week 0
Week 8
Week 14
3.08 ± 0.50
2.99 ± 0.46
2.57 ± 0.54
2.68 ± 0.52
6.47 ± 1.61*
7.72 ± 2.69*
2.70 ± 0.78
5.18 ± 0.75**,***
4.87 ± 1.13**,****
mPAP, mmHg
Week 0
Week 8
Week 14
15.29 ± 2.24
16.87 ± 1.66
17.27 ± 2.77
14.40 ± 3.57
28.64 ± 4.22*
33.72 ± 5.76*
14.56 ± 3.00
27.71 ± 1.72**,***
25.94 ± 3.67**,****
PADP, mmHg
Week 0
Week 8
Week 14
9.41 ± 2.62
11.02 ± 2.24
9.93 ± 2.71
8.70 ± 3.62
20.84 ± 4.72*
24.90 ± 6.10*
9.56 ± 3.21
19.10 ± 2.37**
17.79 ± 3.58**,****
PASP, mmHg
Week 0
Week 8
Week 14
27.96 ± 2.24
29.98 ± 2.29
32.24 ± 3.02
27.30 ± 3.80
45.22 ± 5.48*
52.14 ± 6.63*
27.11 ± 4.70
46.40 ± 3.93**
43.70 ± 4.58**,****
mRVP, mmHg
Week 0
Week 8
Week 14
10.49 ± 1.54
11.10 ± 1.68
11.93 ± 1.48
9.80 ± 3.19
14.96 ± 2.61*
18.52 ± 2.07*
10.11 ± 2.20
14.89 ± 1.83**
15.25 ± 2.45***,****
RVSP, mmHg
Week 0
Week 8
Week 14
32.01 ± 3.69
33.38 ± 3.35
36.06 ± 4.30
32.40 ± 7.03
49.06 ± 6.76*
55.84 ± 5.75*
31.89 ± 6.45
50.00 ± 4.18**
46.40 ± 6.77**,****
PAOP, mmHg
Week 0
Week 8
Week 14
4.57 ± 1.40
5.29 ± 2.14
6.00 ± 1.63
4.70 ± 1.64
6.20 ± 2.25
4.90 ± 2.02
4.89 ± 1.69
5.67 ± 2.83
5.89 ± 2.09
CO, L/min
Week 0
Week 8
Week 14
3.39 ± 0.35
3.86 ± 0.84
4.40 ± 1.24
3.61 ± 0.84
3.55 ± 0.66
4.02 ± 1.10
3.69 ± 0.85
4.22 ± 0.77
4.18 ± 0.63
  1. Values are mean ± SD. *P < 0.05 compared with the control group. **P < 0.05 compared with the control group. *** P < 0.05 compared with value at week 14. ****P < 0.05 compared with the sham group
  2. PVR pulmonary vessel resistance, mPAP mean pulmonary arterial pressure, PADP pulmonary arterial diastolic pressure, PASP pulmonary arterial systolic pressure, mRVP mean right ventricular pressure, RVSP right ventricular systolic pressure, PAOP pulmonary artery occlusion pressure, CO cardiac output