Table 1 CREDENCE trial inclusion and exclusion criteria

Inclusion criteria

 (1) Age ≥18 years

 (2) Patients scheduled to undergo clinically-indicated non-emergent invasive coronary angiography

Exclusion criteria

 (1) Known coronary artery disease (myocardial infarction, percutaneous coronary interventions, coronary artery bypass graft)

 (2) Hemodynamic instability

 (3) Inability to provide written informed consent

 (4) Concomitant participation in another clinical trial in which an individual is subject to investigational drug or device

 (5) Pregnancy or unknown pregnancy status

 (6) Absolute contraindication to iodinated contrast due to prior near-fatal anaphylactoid reaction (laryngospasm, bronchospasm, cardiorespiratory collapse, or equivalent)

 (7) Impaired chronic renal function (serum creatinine ≥1.7 mg/dl or Glomerular Filtration Rate <30 ml/min)

 (8) Baseline irregular heart rhythm (e.g., atrial fibrillation, etc.)

 (9) Heart rate ≥100 beats per minute

 (10) Systolic blood pressure ≤90 mm Hg

 (11) Contraindications to β blockers or nitroglycerin or adenosine