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Table 1 Characteristics of included studies

From: Impact of impaired fractional flow reserve after coronary interventions on outcomes: a systematic review and meta-analysis

First author, year of publication

Design

Indication for PCI

PCI technique

Cut-off for low FFR - group

FFR technique

Definition of MACE

Adenosine

Pressure wire pullback

Bech et al., [18]

Retrospective

Stable angina

POBA

<0.9

i.v.

NA

MACE (death, MI, recurrent angina, CABG, repeated PTCA)

Pijls et al., [31]

Prospective, observational

All comers

“stent” (type NA)

≤ 0.9

i.v. or i.c.

No

MACE (death, MI, CABG, TVR)

Klauss et al., [30]

Retrospective

Stable angina

BMS

< 0.95

i.c.

Not mandatory

MACE (death, MI, TVR)

Nam et al., [19]

Retrospective

2/3 ACS, 1/3 stable angina

DES

≤ 0.9

i.c.

No

MACE (death, MI, TVR)

Leesar et al., [9]

Prospective, interventional

Stable angina

DES > BMS

< 0.96

i.c.

No

MACE (death, MI, TLR)

Ito et al., [23]

Retrospective

92 % stable angina, 8 % unstable angina

DES plus IVUS

≤ 0.9

i.c.

No

MACE (cardiac death, MI, TVR, stent thrombosis)

Reith et al., [24]

Prospective, observational

Stable angina

DES > BMS plus OCT

≤ 0.905

i.c.

No

MACE (death, MI, TLR)

Doh et al., [22]

Prospective, observational

1/3 ACS, 2/3 stable angina

DES plus IVUS

< 0.89

i.v. or i.c.

Not mandatory

TVF (death and MI attributed to target vessel, TVR)

  1. Abbreviations: ACS acute coronary syndrome, AUC area under curve, BMS bare metal stent, CABG coronary artery bypass graft, CI confidence interval, DES drug eluting stent, i.c. intracoronary, i.v. intravenous, IVUS intravascular ultrasound, FFR fractional flow reserve, FU follow up, MACE major adverse cardiac events, MI myocardial infarction, Mo months, N patient number, NA not applicable, OCT optical coherence tomography, TLR target lesion revascularisation, TVF target vessel failure, TVR target vessel revascularisation, PCI percutaneous coronary intervention, POBA plain old balloon angioplasty