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Table 3 Analysis of the impact of input variable variations in categorizing subjects based on ten-year risk threshold of 5 %

From: Impact of clinical input variable uncertainties on ten-year atherosclerotic cardiovascular disease risk using new pooled cohort equations

Patient groups

Base Calculated Ten Year Risk < 5 % (% of total)

Base Calculated Ten Year Risk ≥ 5 % (% of total)

Total Change of Risk Categorization (% of total)

Base Calculated Risk <5 %

No change of risk categorization (Maximal calculated risk <5 %)

Change of risk categorization (Maximal calculated risk ≥5 %)

Base Calculated Risk ≥5 %

No change of risk categorization (Minimal calculated risk ≥5 %)

Change of risk categorization (Minimal calculated Risk <5 %

Non-DM (n = 1292)

28.79

16.02***

12.77

71.21

59.83***

11.38

24.15

 AA (n = 426)

23.47

10.80***

12.67

76.53

65.49***

11.04

23.71

 AA Male (n = 196)

4.08

1.53

2.55

95.92

90.82

5.1

7.65

 AA Female (n = 230)

40.00

18.70***

21.3

60.00

43.91***

16.09

37.39

 White (n = 866)

31.41

18.59***

12.82

68.59

57.04***

11.55

24.36

 White Male (n = 404)

22.77

10.89***

11.88

77.23

66.34***

10.89

22.77

 White Female (n = 462)

38.96

25.32***

13.64

61.04

48.92***

12.12

25.76

  1. Values are % or n. Base calculated: predicted ten-year risk using the raw NHANES data; Minimal Risk: minimum predicted ten-year risk computed by the calculator assuming a variation in age of 0–1 year, and ± 10 % variation in total-cholesterol (c), HDL-c, and systolic blood pressure (BP); Maximal Risk: maximum predicted ten-year risk computed by the calculator assuming a variation in age of 0–1 year, and ± 10 % variation in total-cholesterol (c), HDL-c, and systolic blood pressure (BP); DM: Diabetes mellitus; AA: African-American; Comparisons between Base versus Max/Min Risk were performed using Fisher’s Exact Test; * for P < 0.05, ** for P < 0.01, and *** for P < 0.001