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Table 2 Analysis of the impact of input variable variations in categorizing subjects based on ten-year risk threshold of 7.5 %

From: Impact of clinical input variable uncertainties on ten-year atherosclerotic cardiovascular disease risk using new pooled cohort equations

Patient groups

Base Calculated Ten Year Risk < 7.5 % (% of total)

Base Calculated Ten Year Risk ≥ 7.5 % (% of total)

Total Change of Risk Categorization

(% of total)

Base Calculated Risk <7.5 %

No change of risk categorization (Maximal calculated risk <7.5 %)

Change of risk categorization (Maximal calculated risk ≥7.5 %)

Base Calculated Risk ≥7.5 %

No change of risk categorization (Minimal calculated risk ≥7.5 %)

Change of risk categorization (Minimal calculated Risk <7.5 %

All (n = 1805)

32.96

20.39***

12.57

67.04

55.68***

11.36

23.93

Non-DM (n = 1292)

41.80

26.55***

15.25

58.20

46.90***

11.3

26.55

 AA (n = 426)

36.15

20.42***

15.73

63.85

52.11***

11.74

27.46

 AA Male (n = 196)

14.29

6.63*

7.66

85.71

78.57

7.14

14.80

 AA Female (n = 230)

54.78

32.17***

22.61

45.22

29.57***

15.65

38.26

 White (n = 866)

44.57

29.56***

15.01

55.43

44.34***

11.09

26.10

 White Male (n = 404)

34.90

19.31***

15.59

65.10

52.72***

12.38

27.97

 White Female (n = 462)

53.03

38.53***

14.5

46.97

37.01***

9.96

24.46

DM (n = 513)

10.72

4.87***

5.85

89.28

77.78***

11.5

17.35

 AA (n = 255)

5.88

2.35

3.53

94.12

84.71***

9.41

12.94

 AA Male (n = 107)

0.00

0.00

0

100.00

98.13

1.87

1.87

 AA Female (n = 148)

10.14

4.05

6.09

89.86

75.00**

14.86

20.95

 White (n = 258)

15.50

7.36***

8.14

84.50

70.93***

13.57

21.71

 White Male (n = 130)

10.77

3.85

6.92

89.23

81.54

7.69

14.62

 White Female (n = 128)

20.31

10.94

9.37

79.69

60.16**

19.53

28.91

  1. Values are % or n. Base calculated: predicted ten-year risk using the raw NHANES data; Minimal Risk: minimum predicted ten-year risk computed by the calculator assuming a variation in age of 0–1 year, and ± 10 % variation in total-cholesterol (c), HDL-c, and systolic blood pressure (BP); Maximal Risk: maximum predicted ten-year risk computed by the calculator assuming a variation in age of 0–1 year, and ± 10 % variation in total-cholesterol (c), HDL-c, and systolic blood pressure (BP); DM: Diabetes mellitus; AA: African-American; Comparisons between Base versus Max/Min Risk were performed using Fisher’s Exact Test; * for P < 0.05, ** for P < 0.01, and *** for P < 0.001
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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