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Table 6 Adverse events (Intention to treat analysis, N = 172)

From: Leg edema with (S)-amlodipine vs conventional amlodipine given in triple therapy for hypertension: a randomized double blind controlled clinical trial

Adverse events Test group %, (n/N) Reference group %, (n/N) P
Pitting edema 31.40, (27/86) 46.51, (40/86) 0.0301
Increased urinary frequency 24.41, (21/86) 24.41, (21/86) ns
Muscle cramps 4.65, (4/86) 2.32, (2/86) ns
Rash on face/arms 2.32, (2/86) 0 (0/86) ns
Headache 2.32, (2/86) 3.48, (3/86) ns
Constipation 1.16, (1/86) 2.32 (2/86) ns
Peri-orbital edema 1.16, (1/86) 0 (0/86) ns
Vertigo & dizziness 0 (0/86) 1.16, (1/86) ns
Vasculitic rash on lower limbs 0 (0/86) 1.16, (1/86) ns
Death 1.16, (1/86) 0 (0/86) ns
Total no. of AEs 68.60, (59/86) 81.39, (70/86) 0.03
  1. AE adverse event, N total number of patients, n number of AEs, Fisher’s exact test was applied. p < 0.05 = statistically significant, ns value not significant