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Table 5 Effect of warfarin and antithrombotics on the risk of hemorrhagic stroke

From: Risk of bleeding after hospitalization for a serious coronary event: a retrospective cohort study with nested case-control analyses

 

Cases

(n = 70)

n (%)

Controls

(n = 1000)

n (%)

Odds ratiosa

(95 % CI)

P value

Warfarin

 Non-useb

50 (71.4)

904 (90.4)

1 (−)

 

 Current use

17 (24.3)

83 (8.3)

3.71 (1.66–8.28)

<0.01

   < 1 month

1 (1.4)

4 (0.4)

2.99 (0.27–32.88)

0.37

  1–12 months

5 (7.1)

30 (3.0)

2.14 (0.64–7.08)

0.21

   > 1 year

11 (15.7)

49 (4.9)

6.26 (2.37–16.52)

<0.01

 Recent use

2 (2.9)

5 (0.5)

9.21 (1.43–59.26)

0.02

 Past use

1 (1.4)

8 (0.8)

3.26 (0.34–31.38)

0.31

Antithrombotic

 Non-use AP and non-use warfarinb

3 (4.3)

44 (4.4)

1 (−)

 

 Current AP and non-current warfarin

46 (65.7)

810 (81.0)

0.93 (0.26–3.32)

0.92

 Non-current AP and current warfarin

10 (14.3)

63 (6.3)

2.26 (0.54–9.47)

0.26

 Current AP and current warfarin

7 (10.0)

20 (2.0)

6.36 (1.34–30.16)

0.02

  1. AP antiplatelets
  2. aEstimates adjusted by age, sex, calendar year, time of follow up after serious coronary event, health services utilisation, smoking, proton pump inhibitor, antithrombotic and nonsteroidal anti-inflammatory drug use, type of serious coronary event and prior peptic ulcer disease using a logistic regression model
  3. bReference category