Study | Year | Country | Study design | Population | Age, yrs | Male, n | Mean time intervala | Blindb | Reference test | Index measured using CMR | Field strength |
---|---|---|---|---|---|---|---|---|---|---|---|
Hosch et al. | 2007 | Germany | PC | 19 with newly diagnosed CA and 9 patients with systemic amyloidosis but without CA and 10 healthy, age-matched control | 59 ± 6.1 | 14 | NA | Y | EMB | T1 and T2 RT | 1.5 T |
Vogelsberg et al. | 2008 | Germany | NA | 33 subjects with suspected CA | 64 ± 13 | NA | Same day | Y | EMB | Amyloid LGE pattern | 1.5 T |
Austin et al. | 2009 | USA | RC | 47 subjects with suspected CA | 62 | 33 | 24–48 h | N | EMB | LGE; DHE | 1.5 T |
Ruberg et al. | 2009 | USA | PC | 28 patients with systemic AL amyloidosis | 62 ± 11 | 20 | NA | Y | EMB or clinical criteria | LGE | 1.5 T |
Karamitsos et al. | 2013 | UK/Canada | NA | 53 patients with systemic (primary) AL amyloidosis and 17 patients with aortic stenosis and 36 normal volunteers | 63 ± 10c | 69 | NA | Y | Echocardiography and clinical features | Noncontrast T1 mapping; LGE | 1.5 T |
Aquaro et al. | 2014 | Italy | PC | 59 patients with a previous diagnosis of systemic AL amyloidosis and 20 healthy control subjects | 69 ± 10 | 36 | Same day | Y | Echocardiographic criteria and/or ECG criteria or EMB | SID; conventional LGE | 1.5 T |
White et al. | 2014 | USA | PC | 90 patients with suspected CA and 64 hypertensive patients with LVH | 62 ± 13 | 52 | NA | Y | EMB | LGE pattern: Global HE | 1.5 T |