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Table 3 Relationship between DHA/AA (≥0.903) and ACS, subgroup analysis

From: Association between the docosahexaenoic acid to arachidonic acid ratio and acute coronary syndrome: a multicenter observational study

Subgroup

DHA/AA

ACS

N

Prevalence

Crude OR (95 % CI)

Adjusted OR(95 % CI)

P-value for interaction

Male

≥0.903

47

688

6.8 %

0.572 (0.391, 0.838)

0.389 (0.211, 0.716)

0.01a

 

<0.903

75

660

11.4 %

  

Female

≥0.903

18

179

10.1 %

1.982 (0.910, 4.317)

3.820 (0.718, 20.325)

 

<0.903

11

206

5.3 %

  

Age ≥65

≥0.903

43

539

8.0 %

0.842 (0.528, 1.343)

0.658 (0.329, 1.317)

0.23

 

<0.903

35

375

9.3 %

  

Age <65

≥0.903

22

328

6.7 %

0.620 (0.368, 1.044)

0.312 (0.115, 0.846)

 

<0.903

51

491

10.4 %

  

Diabetes mellitus, yes

≥0.903

25

345

7.2 %

0.576 (0.341, 0.973)

0.424 (0.197, 0.915)

0.31

 

<0.903

40

335

11.9 %

  

Diabetes mellitus, no

≥0.903

40

522

7.7 %

0.875 (0.562, 1.361)

0.758 (0.338, 1.700)

 

<0.903

46

531

8.7 %

  

Hypertension, yes

≥0.903

51

656

7.8 %

0.819 (0.552, 1.216)

0.706 (0.377, 1.320)

0.06a

 

<0.903

57

611

9.3 %

  

Hypertension, no

≥0.903

14

211

6.6 %

0.554 (0.285, 1.078)

0.162 (0.039, 0.670)

 

<0.903

29

255

11.4 %

  

Dyslipidemia, yes

≥0.903

46

612

7.5 %

0.656 (0.443, 0.973)

0.447 (0.237, 0.845)

0.15

 

<0.903

67

608

11.0 %

  

Dyslipidemia, no

≥0.903

19

255

7.5 %

1.013 (0.523, 1.961)

1.139 (0.368, 3.527)

 

<0.903

19

258

7.4 %

  

Smoking history, yes

≥0.903

40

413

6.8 %

0.652 (0.420, 1.010)

0.475 (0.218, 1.031)

0.68

 

<0.903

52

368

14.1 %

  

Smoking history, no

≥0.903

25

454

5.5 %

0.795 (0.467, 1.355)

0.598 (0.265, 1.350)

 

<0.903

34

498

6.8 %

  

Family history of IHD, yes

≥0.903

9

166

5.4 %

0.298 (0.134, 0.661)

0.621 (0.174, 2.219)

0.76

 

<0.903

25

155

16.1 %

  

Family history of IHD, no

≥0.903

56

701

8.0 %

0.925 (0.633, 1.351)

0.499 (0.266, 0.939)

 

<0.903

61

711

8.6 %

  

Chronic kidney disease, yes

≥0.903

18

236

7.6 %

0.607 (0.317, 1.161)

0.738 (0.277, 1.963)

0.40

 

<0.903

23

192

12.0 %

  

Chronic kidney disease, no

≥0.903

21

439

4.8 %

0.582 (0.337, 1.002)

0.439 (0.219, 0.880)

 

<0.903

40

503

8.0 %

  

Obesity (BMI ≥25), yes

≥0.903

23

319

7.2 %

0.707 (0.402, 1.242)

0.909 (0.376, 2.196)

0.19

 

<0.903

31

313

9.9 %

  

Obesity (BMI <25), no

≥0.903

42

516

8.1 %

0.777 (0.508, 1.189)

0.425 (0.206, 0.877)

 

<0.903

53

518

10.2 %

  

History of coronary revascularization, yes

≥0.903

32

232

13.8 %

0.742 (0.452, 1.217)

0.488 (0.243, 0.979)

0.84

 

<0.903

44

248

17.7 %

  

History of coronary revascularization, no

≥0.903

33

635

5.2 %

0.752 (0.470, 1.203)

0.554 (0.211, 1.454)

 

<0.903

42

618

6.8 %

  
  1. aindicates statistical signficance for interaction (P < 0.10), OR = odds ratio, CI = confidence interval, ACS = acute coronary syndrome, DHA/AA = docosahexaenoic acid to arachidonic acid ratio, IHD = ischemic heart disease, BMI = body mass index