Table 2 Echocardiographic parameters and biomarkers. Linear regression models (response variable: Galectin 3). Multivariate analyses adjusted for age, gender, eGFR, treatment with beta-blocker, ACE-inhibitor, Aldosterone Receptor Antagonist, Mineralocorticoid receptor antagonist, beta-blocker
Univariate: Beta (95 %-CI) | P-value | Multivariate: Beta (95 % CI) | P-value | |
|---|---|---|---|---|
Echocardiographic parameters: | ||||
LVIDd | -0.036 (-0.124–-0.510) | 0.410 | -- | -- |
LVmassIndex | 0.442×10−3 (-0.912×10−3–1.796×10−3) | 0.520 | -- | -- |
EF biplane | -0.002 (-0.011–0.007) | 0.691 | -- | -- |
GLS | -0.002 (-0.029–0.024) | 0.861 | -- | -- |
TAPSE | -0.195 (-0.353–-0.038) | 0.015 | -0.073 (-0.211–0.065) | 0.298 |
MV decel time | -9.655×10−5 (-0.001–0.001) | 0.868 | -- | -- |
E/e’ | 0.012 (0.000–0.023) | 0.049 | 0.005 (-0.005–0.014) | 0.338 |
s’ medial | -0.070 (-0.128–-0.011) | 0.020 | -0.014 (-0.065–0.036) | −0.575 |
s’ lateral | -0.035 (-0.090–0.019) | 0.199 | -- | -- |
LAESVi | 0.009 (0.001–0.017) | 0.021 | 0.004 (-0.003–0.011) | 0.222 |
Biomarkers: | ||||
Troponin I | 0.175 (0.008–0.341) | 0.040 | 0.055 (-0.089–0.198) | 0.451 |
NTproBNP | 0.110 (0.072–0.147) | <0.001 | 0.047 (0.008–0.086) | 0.020 |
proANP | 0.320 (0.232–0.407) | <0.001 | 0.137 (0.067–0.207) | <0.001 |
ChromagraninA | 0.203 (0.125–0.280) | <0.001 | 0.123 (0.052–0.194) | <0.001 |
Copeptin | 0.211 (0.139–0.282) | <0.001 | 0.080 (0.000–0.160) | 0.049 |
hsCRP | 0.080 (0.021–0.138) | 0.008 | 0.051 (0.001–0.101) | 0.047 |