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Table 2 Echocardiographic parameters and biomarkers. Linear regression models (response variable: Galectin 3). Multivariate analyses adjusted for age, gender, eGFR, treatment with beta-blocker, ACE-inhibitor, Aldosterone Receptor Antagonist, Mineralocorticoid receptor antagonist, beta-blocker

From: Galectin 3: association to neurohumoral activity, echocardiographic parameters and renal function in outpatients with heart failure

  Univariate: Beta (95 %-CI) P-value Multivariate: Beta (95 % CI) P-value
Echocardiographic parameters:
 LVIDd -0.036 (-0.124–-0.510) 0.410 -- --
 LVmassIndex 0.442×10−3 (-0.912×10−3–1.796×10−3) 0.520 -- --
 EF biplane -0.002 (-0.011–0.007) 0.691 -- --
 GLS -0.002 (-0.029–0.024) 0.861 -- --
 TAPSE -0.195 (-0.353–-0.038) 0.015 -0.073 (-0.211–0.065) 0.298
 MV decel time -9.655×10−5 (-0.001–0.001) 0.868 -- --
 E/e’ 0.012 (0.000–0.023) 0.049 0.005 (-0.005–0.014) 0.338
 s’ medial -0.070 (-0.128–-0.011) 0.020 -0.014 (-0.065–0.036) −0.575
 s’ lateral -0.035 (-0.090–0.019) 0.199 -- --
 LAESVi 0.009 (0.001–0.017) 0.021 0.004 (-0.003–0.011) 0.222
Biomarkers:
 Troponin I 0.175 (0.008–0.341) 0.040 0.055 (-0.089–0.198) 0.451
 NTproBNP 0.110 (0.072–0.147) <0.001 0.047 (0.008–0.086) 0.020
 proANP 0.320 (0.232–0.407) <0.001 0.137 (0.067–0.207) <0.001
 ChromagraninA 0.203 (0.125–0.280) <0.001 0.123 (0.052–0.194) <0.001
 Copeptin 0.211 (0.139–0.282) <0.001 0.080 (0.000–0.160) 0.049
 hsCRP 0.080 (0.021–0.138) 0.008 0.051 (0.001–0.101) 0.047
  1. Abbreviations: LVIDd Left ventricle internal diameter diastoli, LVmassIndex Left ventricle mass index, EF Ejection Fraction, GLS Global longitudinal strain, TAPSE Tricuspid annular plane systolic excursion, MV decel time Mitral valve deceleration time, E/e’, s’ Myocardial peak systolic velocity, LAESVi Left atrial end systolic volume index, NTproBNP N-terminal pro brain natriuretic peptide, proANP Pro atrial natriuretic protein, hsCRP High sensitive C-reactive protein, eGFR Estimated glomerular filtration rate