Table 1 Baseline patient demographics and characteristics
Demographics and characteristics | Placebo (n = 68) | Vernakalant (n = 129) |
|---|---|---|
Sex, n (%) | ||
Male | 45 (66.2) | 76 (58.9) |
Female | 23 (33.8) | 53 (41.1) |
Race, n (%) | ||
White | 65 (95.6) | 123 (95.3) |
Black or African–American | 0 | 5 (3.9) |
Asian | 2 (2.9) | 0 |
American Indian or Alaskan Native | 0 | 1 (0.8) |
Other | 1 (1.5) | 0 |
Country, n (%) | ||
Israel | 24 (35.3) | 49 (38.0) |
USA | 17 (25.0) | 31 (24.0) |
South Africa | 15 (22.1) | 21 (16.3) |
Canada | 9 (13.2) | 20 (15.5) |
Chile | 2 (2.9) | 3 (2.3) |
Mexico | 1 (1.5) | 4 (3.1) |
Peru | 0 | 1 (0.8) |
Age, years, mean (SD) | 60.8 (14.1) | 63.7 (12.7) |
Weight, kg, mean (SD) | 89.8 (17.6) | 86.5 (17.7) |
Classification based on CYP2D6 genotype, n (%) | ||
Extensive metabolizer | 17 (25.0) | 42 (32.6) |
Intermediate metabolizer | 13 (19.1) | 19 (14.7) |
Poor metabolizer | 0 | 4 (3.1) |
Ultra-rapid metabolizer | 0 | 2 (1.6) |
Indeterminate | 1 (1.5) | 4 (3.1) |
Missing | 37 (54.4) | 58 (45.0) |
Number of previous AF episodes, n (%) | ||
0 | 24 (35.3) | 53 (41.1) |
1 | 14 (20.6) | 32 (24.8) |
2 | 15 (22.1) | 15 (11.6) |
3 | 2 (2.9) | 9 (7.0) |
>3 | 13 (19.1) | 20 (15.5) |
Duration of current AF episode, hours, mean (SD) | 41.0 (36.3) | 37.3 (36.6) |
Duration of current AF episode, n (%) | ||
1 day | 28 (41.2) | 62 (48.1) |
2 days | 16 (23.5) | 25 (19.4) |
3 days | 8 (11.8) | 13 (10.1) |
4 days | 5 (7.4) | 8 (6.2) |
5 days | 1 (1.5) | 7 (5.4) |
6 days | 6 (8.8) | 3 (2.3) |
7 days | 0 | 2 (1.6) |
Missing data | 4 (5.9) | 9 (7.0) |
Medical history, n (%) | ||
Hypertension | 39 (57.4) | 89 (69.0) |
Hyperlipidaemia | 39 (57.4) | 62 (48.1) |
Valvular heart disease | 13 (9.1) | 27 (20.9) |
Diabetes mellitus | 16 (23.5) | 18 (14.0) |
Ischaemic heart disease | 12 (17.6) | 18 (14.0) |
Percutaneous transluminal coronary angioplasty | 9 (13.2) | 18 (14.0) |
Syncope, fainting or postural hypotension | 10 (14.7) | 9 (7.0) |
Myocardial infarction | 7 (10.3) | 11 (8.5) |
Angina pectoris | 3 (4.4) | 10 (7.8) |
Atrial flutter | 3 (4.4) | 8 (6.2) |
Coronary artery bypass graft | 3 (4.4) | 5 (3.9) |
Pacemaker | 3 (4.4) | 3 (3.2) |
Ventricular tachycardia | 2 (2.9) | 1 (0.8) |
Symptoms of AF, n (%) | ||
Palpitations | n = 66 | n = 128 |
42 (63.6) | 88 (68.8) | |
Fatigue | n = 65 | n = 128 |
33 (50.8) | 61 (47.7) | |
Chest pain | n = 66 | n = 128 |
5 (7.6) | 17 (13.3) | |
Dyspnoea | n = 66 | n = 128 |
10 (15.2) | 26 (20.3) | |
Dizziness | n = 66 | n = 128 |
13 (19.7) | 20 (15.6) | |