Table 4 GRADE evidence profile: Aspiration thrombectomy (AT) prior to PCI in patients with STEMI
Quality assessment | Summary of findings | Certainty in estimates | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Study event rates | Relative risk (95 % CI) | Anticipated absolute effects over6 months | OR Quality of evidence | ||||||||
No of participants(studies) Range follow-up time | Risk of bias | Inconsistency | Indirectness | Imprecision | Publication bias | Without AT | With AT | Without AT | With AT | ||
Overall mortality (Includes cardiovascular (CV) mortality for studies only reporting CV mortality) | |||||||||||
20866 (20) 6–12 mo | No serious limitations1 | No serious limitations | No serious limitations2 | Serious imprecision1,3 | Undetected | 457/ 10433 | 403/ 10433 | 0.89 (0.78-1.01) | 35 per 10004 | 4 fewer per 1000 (8 fewer to 0 more) | ⊕⊕⊕⊕O MODERATE, due to imprecision |
Recurrent myocardial infarction | |||||||||||
20662 (17) 6–12 mo | No serious limitations 1 | No serious limitations | No serious limitations | Serious imprecision1,5 | Undetected | 246/ 10331 (2.3 %) | 229/10331(2.2 %) | 0.94 (0.79-1.12) | 18 per 10004 | 1 fewer per 1000 (4 fewer to 2 more) | ⊕⊕⊕⊕O MODERATE, due to imprecision |
Stroke | |||||||||||
18348 (8) 6–12 mo | No serious limitations 1 | No serious limitations | No serious limitations | Serious imprecision1,6 | Undetected | 48/ 9163 (0.5 %) | 77/9185 (0.8 %) | 1.56 (1.09-2.24) | 5 per 10004 | 3 more per 1000 (0 more to 6 more) | ⊕⊕⊕⊕O MODERATE, due to imprecision |
Major bleeding | |||||||||||
11655 (4) 6–12 mo | No serious limitations 1 | No serious limitations | No serious limitations | Serious imprecision1,5 | Undetected | 99/5823 (1.7 %) | 101/5832 (1.7 %) | 1.02 (0.78-1.35) | 15 per 10004 | 0 more per 1000 (3 fewer to 5 more) | ⊕⊕⊕⊕O MODERATE, due to imprecision |