# Table 2 Analysis of determinants of arterial stiffness

Model 1: Constant 1.83258 Model 2: Constant 1.74717
Variable Coefficient p-value Coefficient p-value
Phenotype: intermediate 0.09103 0.046 0.12729 0.005
Phenotype: sustainer 0.09103 0.022 0.11514 0.005
BMI: middle tertile 0.07742 <0.001 0.07209 0.002
BMI: high tertile 0.12824 <0.001 0.11146 <0.001
Age: middle tertile 0.09143 <0.001 0.08398 <0.001
Age: high tertile 0.23804 <0.001 0.23729 <0.001
Blood pressure ≥135/85 mmHg 0.10273 <0.001 0.08734 <0.001
Female sex 0.03609 0.377 0.08017 0.065
Interaction: female sex and intermediate phenotype −0.11124 0.043 −0.14789 0.007
Interaction: female sex and sustainer phenotype −0.07442 0.143 −0.09407 0.071
Fasting plasma triglycerides - - 0.05707 0.004
1. Analysis of explanatory factors for supine pulse wave velocity (after logarithmic transformation) in multivariate analysis. The male sex, constrictor phenotype, lowest BMI tertile, lowest age tertile, and BP < 135/85 mmHg served as reference categories in both models, i.e. for these variables the numeric value of the coefficient is 0
2. Model 1 was based on phenotype, BMI-category, age-category, BP-category, and sex. Model 1 formula for log(PWV) ~ Constant + phenotype + BMI-category + AGE-category + BP-category + sex + phenotype*sex
3. Example of interpretation: median log(PWV) for a woman with the sustainer phenotype with BMI and age in the highest tertile and BP ≥ 135/85 mmHg: 1.83258 + 0.09103 + 0.12824 + 0.23804 + 0.10273+ 0.03609 + (-0.07442) = 2.35429; median PWV = exp(2.35429) = 10.53 m/s
4. Model 2 was based on Model 1 and fasting plasma total, LDL, and HDL cholesterol, triglycerides, glucose, and haematocrit
5. Model 2 formula for log(PWV) ~ Constant + phenotype + BMI-category + AGE-category + BP-category + sex + phenotype *sex + 0.05707*plasma triglyceride concentration