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Table 2 Multivariable logistic regression with baseline serum uric acid (UA) as a predictor of the metabolic syndrome (MetS) and its components after seven years, unstratified. The odds ratio (OR) is per 59 μmol/L increase of UA. The group includes the subjects without MetS at baseline

From: Overweight modifies the longitudinal association between uric acid and some components of the metabolic syndrome: The Tromsø Study

 

Number

Cases

OR

95 % CI

P value

Risk of elevated blood pressure

3701

2847

1.15

[1.04–1.27]

0.006

Risk of elevated triglycerides

3693

941

1.32

[1.22–1.42]

<0.001

Risk of low HDL

3690

553

1.27

[1.16–1.39]

<0.001

Risk of elevated fasting glucose

3689

333

1.13

[1.02–1.26]

0.021

Risk of central obesity

3677

1031

1.07

[0.97–1.18]

0.130

Risk of MetS

3660

611

1.29

[1.18–1.41]

<0.001

  1. Covariates: sex, age, systolic blood pressure, total cholesterol, current smoking, physical activity, HbA1c, eGFR, use of diuretics, alcohol consumption, and waist circumference
  2. Elevated blood pressure = blood pressure ≥ 130/85 mm Hg or treated for hypertension, elevated triglycerides = triglycerides ≥ 2.28 mmol/L if time since last meal <4 h and ≥1.7 mmol/L if time since last meal ≥4 h or use of lipid lowering drugs, low HDL = HDL < 1.03 mmol/L in men or <1.30 mmol/L in women, elevated fasting glucose = glucose ≥ 7.8 mmol/L if time since last meal <4 h and ≥5.6 mmol/L if time since last meal ≥4 h or treated for elevated glucose, central obesity = waist circumference ≥ 102 cm in men or ≥88 cm in women, MetS = three or more MetS components
  3. Abbreviations: UA uric acid, OR odds ratio, BMI body mass index, CI confidence interval, HDL high-density lipoprotein, HBA1c hemoglobin A1c, eGFR estimated glomerular filtration rate, MetS metabolic syndrome