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Table 2 Multivariable logistic regression with baseline serum uric acid (UA) as a predictor of the metabolic syndrome (MetS) and its components after seven years, unstratified. The odds ratio (OR) is per 59 μmol/L increase of UA. The group includes the subjects without MetS at baseline

From: Overweight modifies the longitudinal association between uric acid and some components of the metabolic syndrome: The Tromsø Study

  Number Cases OR 95 % CI P value
Risk of elevated blood pressure 3701 2847 1.15 [1.04–1.27] 0.006
Risk of elevated triglycerides 3693 941 1.32 [1.22–1.42] <0.001
Risk of low HDL 3690 553 1.27 [1.16–1.39] <0.001
Risk of elevated fasting glucose 3689 333 1.13 [1.02–1.26] 0.021
Risk of central obesity 3677 1031 1.07 [0.97–1.18] 0.130
Risk of MetS 3660 611 1.29 [1.18–1.41] <0.001
  1. Covariates: sex, age, systolic blood pressure, total cholesterol, current smoking, physical activity, HbA1c, eGFR, use of diuretics, alcohol consumption, and waist circumference
  2. Elevated blood pressure = blood pressure ≥ 130/85 mm Hg or treated for hypertension, elevated triglycerides = triglycerides ≥ 2.28 mmol/L if time since last meal <4 h and ≥1.7 mmol/L if time since last meal ≥4 h or use of lipid lowering drugs, low HDL = HDL < 1.03 mmol/L in men or <1.30 mmol/L in women, elevated fasting glucose = glucose ≥ 7.8 mmol/L if time since last meal <4 h and ≥5.6 mmol/L if time since last meal ≥4 h or treated for elevated glucose, central obesity = waist circumference ≥ 102 cm in men or ≥88 cm in women, MetS = three or more MetS components
  3. Abbreviations: UA uric acid, OR odds ratio, BMI body mass index, CI confidence interval, HDL high-density lipoprotein, HBA1c hemoglobin A1c, eGFR estimated glomerular filtration rate, MetS metabolic syndrome