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Table 2 Intervention tested and event rates in randomized controlled trials

From: Glucagon-like peptide-1 receptor agonists and heart failure in type 2 diabetes: systematic review and meta-analysis of randomized and observational studies

Study Medications used across groups Incretin Control Duration of treatment (weeks)
Type Events Type Events
Trials reporting heart failure
 Inagaki 2012 [38, 39] BG or BG + TZD Exenatide 1/215 Insulin glargine 0/212 26
 NCT00294723 2010 [40, 41] None Liraglutide 1/497 Glimepiride 0/248 104
 NCT00318461 2010 [4244] Metformin Liraglutide 1/724 Placebo 0/121 104
Liraglutide 1/724 Glimepiride 0/242
 NCT00360334 2009 [45] OADs Exenatide 0/118 Insulin glargine 1/116 26
 NCT00614120 2010 [46] Merformin Liraglutide 1/697 Glimepiride 0/231 16
 NCT00701935 2013 [47] None Exenatide 0/43 Placebo 1/37 26
 NCT00838903 2014 [48, 49] Metformin Albiglutide 2/302 Placebo 0/101 156
Albiglutide 2/302 Glimepiride 1/307
 NCT00838916 2014 [50, 51] Metformin ± SU Albiglutide 2/504 Insulin glargine 2/241 156
 NCT00839527 2014 [52] Metformin + glimepiride Albiglutide 0/271 Placebo 1/115 164
Albiglutide 0/271 Pioglitazone 4/277
 NCT00849017 2014 [53] None Albiglutide 1/200 Placebo 2/101 164
 NCT00849056 2014 [54] Pioglitazone ± Metformin Albiglutide 0/150 Placebo 1/151 156
 NCT00855439 2015 [55] Other diabetes medications Exenatide 1/22 Glargine 1/24 78
 NCT00960661 2013 [56, 57] Insulin glargine + metformin Exenatide 0/315 Insulin lispro 1/312 30
 NCT01064687 2015 [58] Metformin and pioglitazone Dulaglutide 1/559 Placebo 0/141 26
Exenatide 0/278 Placebo 0/141
 NCT01075282 2015 [59] Metformin and glimepiride Dulaglutide 3/545 Insulin glargine 1/262 78
 NCT01126580 2015 [60, 61] None Dulaglutide 1/539 Metformin 0/268 52
 NCT01191268 2014 [62] Insulin lispro Dulaglutide 0/588 Insulin glargine 1/296 52
 NCT01512108 2014 [63] None Liraglutide 1/240 Additional OAD 0/120 52
 NCT01620489 2014 [64] OAD and/or insulin Liraglutide 1/140 Placebo 0/137 26
 Pratley 2013 [65] SU ± metformin Taspoglutide 0/494 Pioglitazone 2/257 24
Trials reporting hospitalization for heart failure
 Bentley-Lewis 2015 (ELIXA) [15, 16] Metformin, SU, glinide, TZD, insulin, metformin and SU, insulin and OADs, or other diabetes medications Lixisenatide 122/3034 Placebo 127/3034 100
  1. BG biguanide, TZD thiazolidinedione, OADs oral antidiabetic drugs, SU sulfonylurea