Study | Medications used across groups | Incretin | Control | Duration of treatment (weeks) | ||
---|---|---|---|---|---|---|
Type | Events | Type | Events | |||
Trials reporting heart failure | ||||||
BG or BG + TZD | Exenatide | 1/215 | Insulin glargine | 0/212 | 26 | |
None | Liraglutide | 1/497 | Glimepiride | 0/248 | 104 | |
Metformin | Liraglutide | 1/724 | Placebo | 0/121 | 104 | |
Liraglutide | 1/724 | Glimepiride | 0/242 | |||
 NCT00360334 2009 [45] | OADs | Exenatide | 0/118 | Insulin glargine | 1/116 | 26 |
 NCT00614120 2010 [46] | Merformin | Liraglutide | 1/697 | Glimepiride | 0/231 | 16 |
 NCT00701935 2013 [47] | None | Exenatide | 0/43 | Placebo | 1/37 | 26 |
Metformin | Albiglutide | 2/302 | Placebo | 0/101 | 156 | |
Albiglutide | 2/302 | Glimepiride | 1/307 | |||
Metformin ± SU | Albiglutide | 2/504 | Insulin glargine | 2/241 | 156 | |
 NCT00839527 2014 [52] | Metformin + glimepiride | Albiglutide | 0/271 | Placebo | 1/115 | 164 |
Albiglutide | 0/271 | Pioglitazone | 4/277 | |||
 NCT00849017 2014 [53] | None | Albiglutide | 1/200 | Placebo | 2/101 | 164 |
 NCT00849056 2014 [54] | Pioglitazone ± Metformin | Albiglutide | 0/150 | Placebo | 1/151 | 156 |
 NCT00855439 2015 [55] | Other diabetes medications | Exenatide | 1/22 | Glargine | 1/24 | 78 |
Insulin glargine + metformin | Exenatide | 0/315 | Insulin lispro | 1/312 | 30 | |
 NCT01064687 2015 [58] | Metformin and pioglitazone | Dulaglutide | 1/559 | Placebo | 0/141 | 26 |
Exenatide | 0/278 | Placebo | 0/141 | |||
 NCT01075282 2015 [59] | Metformin and glimepiride | Dulaglutide | 3/545 | Insulin glargine | 1/262 | 78 |
None | Dulaglutide | 1/539 | Metformin | 0/268 | 52 | |
 NCT01191268 2014 [62] | Insulin lispro | Dulaglutide | 0/588 | Insulin glargine | 1/296 | 52 |
 NCT01512108 2014 [63] | None | Liraglutide | 1/240 | Additional OAD | 0/120 | 52 |
 NCT01620489 2014 [64] | OAD and/or insulin | Liraglutide | 1/140 | Placebo | 0/137 | 26 |
 Pratley 2013 [65] | SU ± metformin | Taspoglutide | 0/494 | Pioglitazone | 2/257 | 24 |
Trials reporting hospitalization for heart failure | ||||||
Metformin, SU, glinide, TZD, insulin, metformin and SU, insulin and OADs, or other diabetes medications | Lixisenatide | 122/3034 | Placebo | 127/3034 | 100 |