Study | International study | Number of countries involved | Number of study sites | Study phase | Total number of patients randomized | Length of follow up (weeks) | Male (n,%) | Mean age (years) | Mean BMI (kg/m2) | Mean HbA1c (%) | Mean FPG (mmol/L) | Mean diabetes duration (years) |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Trials reporting heart failure | ||||||||||||
No | 1 | NR | III | 427 | 26 | 290 (67.9) | 56.8 | 26.1 | 8.5 | NR | 9.0 | |
Yes | 2 | 138 | III | 746 | 104 | 371 (49.7) | 53.0 | 33.1 | 8.3 | 9.4 | 5.4 | |
Yes | 21 | 170 | III | 1091 | 104 | 635 (58.2) | 56.7 | 31.0 | 8.4 | 10.0 | 7.6 | |
 NCT00360334 2009 [45] | No | 1 | 35 | III | 235 | 26 | 160 (68.4) | 56.6 | NR | NR | NR | 6.0 |
 NCT00614120 2010 [46] | Yes | 3 | 51 | III | 929 | 16 | 514 (55.3) | 53.3 | 25.6 | NR | NR | 7.5 |
 NCT00701935 2013 [47] | Yes | 2 | 17 | II | 80 | 26 | 42 (52.5) | 58.1 | NR | NR | NR | NR |
Yes | 10 | 289 | III | 1049 | 164 | 482 (47.6) | 54.5 | 32.6 | 8.1 | 9.2 | 6.0 | |
Yes | 4 | 222 | III | 779 | 164 | 418 (56.1) | 55.5 | 33.1 | 8.3 | 9.5 | 8.8 | |
 NCT00839527 2014 [52] | Yes | 9 | 358 | III | 685 | 164 | 353 (53.2) | 55.2 | NR | NR | NR | NR |
 NCT00849017 2014 [53] | Yes | 3 | 262 | III | 309 | 164 | 166 (55.1) | 52.9 | NR | NR | NR | NR |
 NCT00849056 2014 [54] | Yes | 6 | 331 | III | 310 | 156 | 180 (59.8) | 55.0 | NR | NR | NR | NR |
 NCT00855439 2015 [55] | No | 1 | 1 | NR | 46 | 82 | 26 (56.5) | 53.0 | NR | NR | NR | NR |
Yes | 17 | 108 | III | 637 | 30 | 261 (51.2) | 59.5 | 32.5 | 8.2 | 7.1 | 11.5a | |
 NCT01064687 2015 [58] | Yes | 3 | 89 | III | 978 | 26 | 570 (58.4) | 55.7 | 33.2 | 8.1 | 9.0 | 8.8 |
 NCT01075282 2015 [59] | Yes | 20 | 78 | III | 810 | 78 | 353 (51.3) | 56.7 | 31.6 | 8.1 | 9.1 | 9.1 |
Yes | 19 | 91 | III | 807 | 56 | 353 (43.7) | 55.6 | 33.3 | 7.6 | 9.0 | 2.6 | |
 NCT01191268 2014 [62] | Yes | 16 | 101 | III | 884 | 52 | 473 (53.5) | 59.4 | 32.5 | 8.5 | NR | 12.7 |
 NCT01512108 2014 [63] | No | 1 | 36 | III | 363 | 52 | 262 (72.8) | 59.5 | NR | 8.1 | 8.8 | NR |
 NCT01620489 2014 [64] | Yes | 6 | 50 | III | 277 | 26 | 140 (50.5) | 67.2 | NR | NR | NR | NR |
 Pratley 2013 [65] | Yes | 17 | 130 | III | 760 | 24 | 362 (48.9) | 56.4 | 32.7 | 8.3 | 10.0 | 8.8 |
Trials reporting hospitalization for heart failure | ||||||||||||
Yes | 49 | NR | III | 6068 | 108b | 4207 (69.3) | 60.3 | 30.2 | 7.7 | 8.2 | 9.3 |