Table 4 Risk of a cerebrovascular event in patients with atrial fibrillation considering comorbidity (Cox regression analysis, n = 1830)

Age (years)^a

1.06 (1.03–1.08)

<0.001

1.05 (1.03–1.07)

<0.001

Men

0.82 (0.61–1.1)

0.19

1.1 (0.76–1.5)

0.74

Comorbidity^a

 CHADS₂ score^b

1.7 (1.5–1.9)

<0.001

1.5 (1.3–1.7)^c

<0.001

 CHA₂DS₂-VASc score^b

1.5 (1.3–1.6)

<0.001

1.4 (1.2–1.6)^d

<0.001

 Charlson Comorbidity Index^b

1.3 (1.2–1.4)

<0.001

1.1 (0.97–1.2)^c

0.14

  Myocardial infarction

0.87 (0.54–1.4)

0.55

0.64 (0.39–1.0)

0.075

  Heart failure

1.2 (0.75–1.8)

0.48

0.90 (0.57–1.4)

0.65

  Peripheral vascular disease

1.9 (1.2–2.9)

0.006

1.5 (0.94–2.3)

0.093

  Cerebrovascular event

5.6 (4.1–7.5)

<0.001

5.2 (3.8–7.2)

<0.001

  Dementia

1.9 (0.93–3.8)

0.081

1.0 (0.48–2.1)

0.99

  Chronic pulmonary disease

0.24 (0.034–1.7)

0.16

0.17 (0.024–1.2)

0.081

  History of peptic ulcers

0.83 (0.46–1.5)

0.53

0.74 (0.41–1.3)

0.32

  Liver disease

1.6 (0.82–3.1)

0.17

1.4 (0.69–2.8)

0.36

  Diabetes

1.2 (0.80–1.7)

0.44

1.3 (0.87–1.9)

0.21

  Hemiplegia

1.6 (0.61–4.4)

0.32

0.63 (0.23–1.8)

0.38

  Renal disease

1.4 (1.2–1.7)

<0.001

1.3 (1.1–1.6)

0.006

  History of tumours

1.3 (0.90–2.0)

0.15

1.1 (0.74–1.7)

0.59

  Leukaemia

3.3 (0.46–24)

0.23

3.1 (0.42–23)

0.27

  Lymphoma

0.049 (0.0–2923)

0.59

0.0 (0.0–5.0 × e²⁶¹)

0.96

 Hypertension

0.98 (0.73–1.3)

0.92

0.94 (0.69–1.3)

0.69

 Valve disease

0.89 (0.53–1.5)

0.65

0.81 (0.48–1.4)

0.44