Table 3 Association of comorbidity and the development of atrial fibrillation within different age strata (binary conditional logistic regression analysis, n = 8452)

Cardiovascular medication^a

 Diuretic

1.6 (1.3–2.0)^*

1.1 (0.82–1.4)

2.0 (1.7–2.4)^*

1.3 (1.0–1.6)^$

1.2 (0.86–1.6)

0.77 (0.54–1.1)

 β blocker

2.2 (1.8–2.7)^*

1.8 (1.5–2.3)^*

2.0 (1.7–2.4)^*

1.6 (1.3–1.9)^*

1.4 (1.0–1.9)^$

1.2 (0.80–1.7)

 Calcium channel blocker

1.7 (1.3–2.2)^*

1.2 (0.87–1.5)

2.1 (1.7–2.6)^*

1.6 (1.3–2.0)^*

1.1 (0.76–1.6)

0.89 (0.58–1.4)

 ACE-inhibitor

1.7 (1.3–2.1)^*

1.1 (0.86–1.5)

1.8 (1.5–2.3)^*

1.2 (0.91–1.5)

2.1 (1.5–2.9)^*

1.7 (1.1–2.6)^$

 ARB

1.8 (1.4–2.4)^*

1.2 (0.89–1.7)

1.5 (1.1–1.9)^$

0.89 (0.64–1.2)

0.82 (0.45–1.5)

0.81 (0.42–1.6)

Comorbidity^a

 Charlson Comorbidity Index (per point increase)

1.2 (1.1–1.3)^*

1.1 (1.0–1.2)^μ,$

1.1 (1.1–1.2)^*

1.1 (1.0–1.2)^μ,*

1.0 (0.94–1.1)

1.0 (0.93–1.1)^μ

  Myocardial infarction

2.2 (1.6–2.9)^*

1.4 (0.97–1.9)^£

1.7 (1.3–2.1)^*

1.2 (0.89–1.6)

1.6 (1.1–2.3)^$

1.3 (0.89–2.0)

  Heart failure

4.4 (2.8–7.0)^*

3.0 (1.8–5.0)^*

3.6 (2.7–4.8)^*

2.8 (2.0–3.9)^*

2.4 (1.8–3.4)^*

2.2 (1.5–3.2)^*

  Peripheral vascular disease

1.6 (1.1–2.3)^$

1.2 (0.79–1.8)

1.5 (1.1–2.0)^$

0.93 (0.68–1.3)

0.99 (0.62–1.6)

0.83 (0.49–1.4)

  Cerebrovascular event

2.1 (1.6–2.9)^*

1.7 (1.2–2.4)^*

1.7 (1.4–2.2)^*

1.5 (1.2–1.9)^$

0.98 (0.72–1.4)

0.84 (0.59–1.2)

  Dementia

1.0 (0.33–3.0)

1.7 (0.51–5.3)

0.91 (0.60–1.4)

0.90 (0.56–1.4)

0.85 (0.55–1.3)

0.74 (0.45–1.2)

  Chronic pulmonary disease

1.3 (0.75–2.4)

1.4 (0.77–2.6)

0.94 (0.57–1.6)

0.84 (0.50–1.4)

0.76 (0.37–1.6)

0.74 (0.34–1.6)

  History of peptic ulcers

1.1 (0.75–1.5)

0.85 (0.58–1.2)

1.3 (0.97–1.7)^£

1.1 (0.78–1.4)

1.1 (0.71–1.7)

1.1 (0.71–1.8)

  Liver disease

1.7 (1.1–2.6)^$

1.4 (0.87–2.2)

0.88 (0.55–1.4)

0.83 (0.50–1.3)

0.54 (0.20–1.5)

0.48 (0.17–1.4)

  Diabetes

1.8 (1.4–2.3)^*

1.3 (0.98–1.7)^£

1.4 (1.2–1.7)^*

1.1 (0.83–1.3)

0.72 (0.49–1.1)

0.60 (0.39–0.92)^$

  Hemiplegia

1.6 (0.66–3.8)

0.87 (0.31–2.5)

1.5 (0.78–2.7)

1.1 (0.53–2.1)

1.6 (0.69–3.5)

1.8 (0.77–4.4)

  Renal disease

1.6 (1.0–2.5)^$

1.1 (0.69–1.9)

1.6 (1.2–2.1)^*

1.4 (1.0–1.8)^$

1.4 (1.1–1.9)^$

1.5 (1.1–2.1)^$

  History of tumours

0.92 (0.70–1.2)

0.83 (0.61–1.1)

1.1 (0.85–1.3)

1.0 (0.81–1.3)

0.63 (0.43–0.92)^$

0.60 (0.40–0.91)^$

  Leukaemia

0.61 (0.07–5.1)

NA

0.85 (0.24–3.0)

0.87 (0.23–3.3)

0.72 (0.08–6.2)

0.97 (0.10–9.0)

  Lymphoma

1.2 (0.25–6.1)

2.3 (0.36–15)

0.49 (0.14–1.7)

0.52 (0.15–1.8)

1.2 (0.24–5.9)

0.84 (0.14–4.9)

 Hypertension

1.5 (1.2–1.8)^*

1.0 (0.82–1.3)

1.6 (1.3–1.8)^*

1.1 (0.91–1.3)

1.4 (1.1–1.8)^$

1.4 (1.0–1.8)^$

 Valve disease

3.1 (2.0–4.7)^*

2.4 (1.5–3.9)^*

2.9 (2.2–3.9)^*

2.2 (1.6–3.0)^*

3.7 (2.4–5.8)^*

3.3 (2.1–5.3)^*