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Table 2 Measurements of left ventricular (LV) function in rats by M-mode echocardiography from the parasternal short axis at the mid papillary muscle level, and colourful-Doppler across the mitral valve from the apical four chamber views

From: Left ventricular deformation associated with cardiomyocyte Ca2+ transients delay in early stage of low-dose of STZ and high-fat diet induced type 2 diabetic rats

 

6 Weeks

12 Weeks

P-value

 

Control Rats

Model Rats

Control Rats

Model Rats

P1

P2

P3

P4

(n = 8)

(n = 8)

(n = 8)

(n = 7)

AWD(mm)

1.82 ± 0.20

1.82 ± 0.17

1.74 ± 0.22

1.74 ± 0.25

0.9445

0.4912

0.7806

0.3278

AWS (mm)

2.86 ± 0.39

2.89 ± 0.32

2.59 ± 0.38

2.43 ± 0.19

0.9521

0.1701

0.2972

0.0091

PWD (mm)

2.15 ± 0.22

2.01 ± 0.33

1.87 ± 0.19

1.70 ± 0.23

0.3284

0.1142

0.0230*

0.0652

EDD (mm)

7.44 ± 0.39

7.69 ± 0.99

7.47 ± 0.57

7.58 ± 0.57

0.5227

0.7959

0.6183

0.6498

EF (%)

72.61 ± 6.38

68.19 ± 8.64

66.37 ± 7.06

59.34 ± 5.27

0.2641

0.0629

0.0724

0.0651

FS (%)

43.33 ± 5.46

39.82 ± 7.03

38.22 ± 5.74

32.69 ± 3.65

0.2842

0.0613

0.0748

0.0330*

EDV (ml)

293.78 ± 32.90

321.15 ± 93.93

308.12 ± 51.21

299.13 ± 58.17

0.4496

0.8122

0.5800

0.6012

ESV (ml)

80.28 ± 19.33

106.38 ± 48.40

105.11 ± 31.42

124.43 ± 35.19

0.1784

0.2979

0.0782

0.4485

E/A Ratio

1.54 ± 0.17

1.83 ± 0.51

1.68 ± 0.26

1.56 ± 0.18

0.1477

0.3586

0.2440

0.2109

MVDT(ms)

14.17 ± 5.80

17.45 ± 8.91

16.03 ± 2.56

16.77 ± 2.96

0.3969

0.6258

0.4473

0.8504

  1. Data are presented as mean ± SD. Abbreviations AWD anterior wall in diastole, AWS anterior wall in systole, PWD posterior wall in diastole, EDD end-diastolic diameter, EF ejection fraction, FS fractional shortening, EDV end-diastolic volume, ESV end-systolic volume, E/A Ratio ratio of the early (E) to late (A) ventricular filling velocities, MVDT mitral valve deceleration time
  2. P1 and P2, Model group compared to control group; P3 and P4, 12-week compared to 6-week group, *P<0.05