| |
Sham
|
MI-CON
|
MI-GFP
|
MI-SiRNA
|
MI-Sema
|
MI-PBS
|
|---|
|
n
|
9
|
9
|
10
|
11
|
11
|
9
|
|---|
|
Infarct size (%)
| |
42.7 ± 5.1
|
42.9 ± 4.7
|
44.3 ± 5.2
|
43.5 ± 4.2**
|
41.3 ± 4.9
|
|
HR (beats/min)
|
419.2 ± 19.1
|
424.5 ± 17.2*
|
421.4 ± 21.2
|
427.3 ± 19.2
|
419.2 ± 19.1**
|
420.1 ± 19.2
|
|
MAP (mmHg)
|
109.2 ± 3.7
|
92.4 ± 6.4*
|
93.2 ± 7.9
|
89.7 ± 8.1
|
92.7 ± 7.3**
|
93.7 ± 7.7
|
|
LVDSP (mmHg)
|
2.92 ± 0.97
|
6.3 ± 1.2*
|
5.8 ± 1.4
|
5.7 ± 1.6
|
6.1 ± 1.9**
|
5.9 ± 1.4
|
|
LVESP (mmHg)
|
119.3 ± 9.2
|
91.2 ± 5.9*
|
89.2 ± 6.1
|
90.2 ± 7.1**
|
88.3 ± 6.8**
|
91.4 ± 7.1
|
|
EDV (μl)
|
309.4 ± 21.3
|
483.2 ± 33.7*
|
467.6 ± 41.4
|
475.1 ± 48.1**
|
471.3 ± 47.4**
|
469.3 ± 45.3
|
|
ESV (μl)
|
106.1 ± 114
|
293.4 ± 19.4*
|
289.2 ± 23.1
|
291.2 ± 24.1**
|
289.4 ± 27.3**
|
285.7 ± 24.2**
|
|
EF (%)
|
61.2 ± 1.7
|
34.7 ± 0.7*
|
35.3 ± 06
|
34.9 ± 0.8
|
34.2 ± 0.9**
|
33.9 ± 1.0
|
|
dP/dtmax (mmHg/s)
|
5517.4 ± 129
|
3696.2 ± 90.2*
|
3712.7 ± 91.8
|
3637.4 ± 83.7
|
3707.2 ± 73.1**
|
3684.3 ± 80.5
|
|
dP/dtmin (mmHg/s)
|
−3989.1 ± 147
|
−2379.4 ± 77.5*
|
−2394.7 ± 90.3
|
−2427.4 ± 84.3
|
−2312.5 ± 74.9**
|
−2419.4 ± 94.2
|
- Values are presented as means ± SD. HR, heart rate; MAP mean arterial pressure, LVEDP LV end-diastolic pressure, LVESP LV end-systolic pressure, EDV end-diastolic volume, ESV end-systolic volume, EF ejection fraction, dP/dtmax and dP/dtmin maximal slope of the systolic pressure increment and the diastolic pressure decrement, respectively.*
P < 0.05 vs. sham group, **
P > 0.05 among various MI groups
