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Table 1 Hemodynamic data based on pressure-volume and infarct size 5 weeks after MI

From: Semaphorin 3A attenuates cardiac autonomic disorders and reduces inducible ventricular arrhythmias in rats with experimental myocardial infarction

  Sham MI-CON MI-GFP MI-SiRNA MI-Sema MI-PBS
n 9 9 10 11 11 9
Infarct size (%)   42.7 ± 5.1 42.9 ± 4.7 44.3 ± 5.2 43.5 ± 4.2** 41.3 ± 4.9
HR (beats/min) 419.2 ± 19.1 424.5 ± 17.2* 421.4 ± 21.2 427.3 ± 19.2 419.2 ± 19.1** 420.1 ± 19.2
MAP (mmHg) 109.2 ± 3.7 92.4 ± 6.4* 93.2 ± 7.9 89.7 ± 8.1 92.7 ± 7.3** 93.7 ± 7.7
LVDSP (mmHg) 2.92 ± 0.97 6.3 ± 1.2* 5.8 ± 1.4 5.7 ± 1.6 6.1 ± 1.9** 5.9 ± 1.4
LVESP (mmHg) 119.3 ± 9.2 91.2 ± 5.9* 89.2 ± 6.1 90.2 ± 7.1** 88.3 ± 6.8** 91.4 ± 7.1
EDV (μl) 309.4 ± 21.3 483.2 ± 33.7* 467.6 ± 41.4 475.1 ± 48.1** 471.3 ± 47.4** 469.3 ± 45.3
ESV (μl) 106.1 ± 114 293.4 ± 19.4* 289.2 ± 23.1 291.2 ± 24.1** 289.4 ± 27.3** 285.7 ± 24.2**
EF (%) 61.2 ± 1.7 34.7 ± 0.7* 35.3 ± 06 34.9 ± 0.8 34.2 ± 0.9** 33.9 ± 1.0
dP/dtmax (mmHg/s) 5517.4 ± 129 3696.2 ± 90.2* 3712.7 ± 91.8 3637.4 ± 83.7 3707.2 ± 73.1** 3684.3 ± 80.5
dP/dtmin (mmHg/s) −3989.1 ± 147 −2379.4 ± 77.5* −2394.7 ± 90.3 −2427.4 ± 84.3 −2312.5 ± 74.9** −2419.4 ± 94.2
  1. Values are presented as means ± SD. HR, heart rate; MAP mean arterial pressure, LVEDP LV end-diastolic pressure, LVESP LV end-systolic pressure, EDV end-diastolic volume, ESV end-systolic volume, EF ejection fraction, dP/dtmax and dP/dtmin maximal slope of the systolic pressure increment and the diastolic pressure decrement, respectively.* P < 0.05 vs. sham group, ** P > 0.05 among various MI groups