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Table 3 PSM-adjusted follow-up (2 years and 3 years) healthcare utilization for hyperlipidemic patients with and without new CV events, categorized by CVD risk level

From: Clinical and economic burden associated with cardiovascular events among patients with hyperlipidemia: a retrospective cohort study

 

History of CV event cohort

 

Modified CHD RE cohort

 

Moderate-risk cohort

 

Low-risk cohort

 

Without CV events

With CV events

Without CV events

With CV events

Without CV events

With CV events

Without CV events

With CV events

(N = 10,741)

(N = 10,741)

(N = 90,614)

(N = 90,614)

(N = 7,938)

(N = 7,938)

(N = 12,527)

(N = 12,527)

N/Mean [%]/(SD)

N/Mean [%]/(SD)

P-valuea

N/Mean [%]/(SD)

N/Mean [%]/(SD)

P-valuea

N/Mean [%]/(SD)

N/Mean [%]/(SD)

P-valuea

N/Mean [%]/(SD)

N/Mean [%]/(SD)

P-valuea

All-cause Healthcare Utilization 2 Years Post-index Date

 Number of Continuous Enrollment Patients

5928[55.2 %]

5576[51.9 %]

<0.0001

58916[65.0 %]

53212[58.7 %]

<0.0001

5096[64.2 %]

4662[58.7 %]

<0.0001

8844[70.6 %]

7822[62.4 %]

<0.0001

 Inpatient LOS (days)

1.50(7.21)

4.14(16.22)

<0.0001

0.71(4.81)

2.10(9.46)

<0.0001

0.60(4.09)

1.78(9.78)

<0.0001

0.24(1.70)

0.76(4.36)

<0.0001

 Number of Visits (PPPM)

            

 Inpatient stays

0.02(0.05)

0.04(0.09)

<0.0001

0.01(0.04)

0.03(0.07)

<0.0001

0.01(0.03)

0.02(0.06)

<0.0001

0.00(0.02)

0.01(0.04)

<0.0001

 Outpatient Visitsb

1.72(1.70)

2.07(2.01)

<0.0001

1.26(1.36)

1.63(1.65)

<0.0001

0.97(1.09)

1.27(1.31)

<0.0001

0.73(0.95)

0.97(1.13)

<0.0001

 Outpatient ER Visits

0.03(0.08)

0.05(0.13)

<0.0001

0.02(0.06)

0.04(0.09)

<0.0001

0.02(0.05)

0.03(0.08)

<0.0001

0.01(0.04)

0.02(0.07)

<0.0001

 Outpatient Pharmacy Visits

1.63(1.52)

1.96(1.70)

<0.0001

1.36(1.28)

1.78(1.49)

<0.0001

1.22(1.15)

1.67(1.34)

<0.0001

0.62(0.87)

1.22(1.14)

<0.0001

 Outpatient Office Visits

0.86(0.86)

0.94(0.94)

<0.0001

0.71(0.78)

0.83(0.82)

<0.0001

0.56(0.67)

0.67(0.74)

<0.0001

0.46(0.67)

0.53(0.64)

<0.0001

All-cause Healthcare Utilization 3 Years Post-index Date

 Number of Continuous Enrollment Patients

3994[37.2 %]

3533[32.9 %]

<0.0001

44654[49.3 %]

38489[42.5 %]

<0.0001

3903[49.2 %]

3485[43.9 %]

<0.0001

7188[57.4 %]

5971[47.7 %]

<0.0001

 Inpatient LOS (days)

1.38(7.05)

3.72(14.25)

<0.0001

0.69(4.98)

1.77(8.28)

<0.0001

0.72(5.43)

1.68(8.17)

<0.0001

0.29(2.57)

0.72(5.57)

<0.0001

 Number of visits (PPPM)

            

 Inpatient Stays

0.02(0.05)

0.04(0.09)

<0.0001

0.01(0.04)

0.02(0.07)

<0.0001

0.01(0.03)

0.02(0.07)

<0.0001

0.00(0.02)

0.01(0.04)

<0.0001

 OutpatientVisitsb

1.64(1.74)

1.97(2.14)

<0.0001

1.24(1.41)

1.55(1.65)

<0.0001

0.96(1.18)

1.22(1.35)

<0.0001

0.77(0.97)

0.91(1.16)

<0.0001

 Outpatient ER Visits

0.03(0.08)

0.05(0.11)

<0.0001

0.02(0.05)

0.03(0.10)

<0.0001

0.01(0.04)

0.03(0.09)

<0.0001

0.01(0.04)

0.02(0.06)

<0.0001

 Outpatient Pharmacy Visits

1.62(1.49)

1.94(1.70)

<0.0001

1.36(1.29)

1.75(1.49)

<0.0001

1.22(1.15)

1.60(1.31)

<0.0001

0.69(0.91)

1.20(1.15)

<0.0001

 Outpatient Office Visits

0.83(0.86)

0.87(0.89)

0.043

0.70(0.78)

0.79(0.81)

<0.0001

0.55(0.66)

0.65(0.75)

<0.0001

0.48(0.69)

0.51(0.63)

0.012

  1. PSM propensity score matching, CVD cardiovascular disease, CV cardiovascular, CHD RE coronary heart disease risk equivalent, SD standard deviation, LOS length of stay, PPPM per patient per month, ER emergency room
  2. aChi-square tests were used to evaluate the statistical significance of differences in categorical variables; student t-tests were used for the continuous variables
  3. bOutpatient visits included emergency room, laboratory/pathology, radiology, outpatient surgical or diagnostic procedure and office visits