History of CV event cohort | Modified CHD RE cohort | Moderate risk cohort | Low risk cohort | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Without CV events | With CV events | Without CV events | With CV events | Without CV events | With CV events | Without CV events | With CV events | |||||
(N = 10741) | (N = 10741) | (N = 90614) | (N = 90614) | (N = 7938) | (N = 7938) | (N = 12527) | (N = 12527) | |||||
N/Mean [%]/(SD) | N/Mean [%]/(SD) | P-valuea | N/Mean [%]/(SD) | N/Mean [%]/(SD) | P-valuea | N/Mean [%]/(SD) | N/Mean [%]/(SD) | P-valuea | N/Mean [%]/(SD) | N/Mean [%]/(SD) | P-valuea | |
All-cause healthcare utilization 1 month (acute phase) post-index date | ||||||||||||
Number of continuous enrollment patients | 10577[98.5 %] | 10282[95.7 %] | <0.0001 | 89539[98.8 %] | 88196[97.3 %] | <0.0001 | 7845[98.8 %] | 7727[97.3 %] | <0.0001 | 12428[99.2 %] | 12317[98.3 %] | <0.0001 |
Inpatient LOS (days) | 0.25(1.94) | 6.43(6.94) | <0.0001 | 0.07(0.90) | 5.22(5.39) | <0.0001 | 0.04(0.61) | 4.97(4.91) | <0.0001 | 0.01(0.35) | 4.42(4.08) | <0.0001 |
Number of patients with Inpatient Visits | 346[3.3 %] | 10282[100.0 %] | <0.0001 | 1102[1.2 %] | 88196[100.0 %] | <0.0001 | 59[0.8 %] | 7727[100.0 %] | <0.0001 | 32[0 .3 %] | 12317[100.0 %] | <0.0001 |
Number of patients with Outpatient ER Visits | 387[3.7 %] | 1503[14.6 %] | <0.0001 | 1674[1.9 %] | 15425[17.5 %] | <0.0001 | 124[1.6 %] | 1663[21.5 %] | <0.0001 | 128[1.0 %] | 3194[25.9 %] | <0.0001 |
Number of patients with Outpatient Office Visits | 5431[51.3 %] | 7141[69.5 %] | <0.0001 | 39190[43.8 %] | 67063[76.0 %] | <0.0001 | 2857[36.4 %] | 5654[73.2 %] | <0.0001 | 3110[25.0 %] | 9311[75.6 %] | <0.0001 |
Number of patients with Outpatient Visitsb | 7297[69.0 %] | 9296[90.4 %] | <0.0001 | 50185[56.0 %] | 81329[92.2 %] | <0.0001 | 3616[46.1 %] | 7078[91.6 %] | <0.0001 | 3895[31.3 %] | 11266[91.5 %] | <0.0001 |
Number of patients with Outpatient Pharmacy Visits | 6842[64.7 %] | 7253[70.5 %] | <0.0001 | 56480[63.1 %] | 67216[76.2 %] | <0.0001 | 4736[60.4 %] | 6266[81.1 %] | <0.0001 | 3500[28.2 %] | 9242[75.0 %] | <0.0001 |
Number of visits (PPPM) | ||||||||||||
Inpatient stays | 0.04(0.21) | 1.18 (0.48) | <0.0001 | 0.01(0.13) | 1.14(0.42) | <0.0001 | 0.01(0.11) | 1.13(0.40) | <0.0001 | 0.00(0.06) | 1.11(0.36) | <0.0001 |
Outpatient Visitsb | 2.06(2.76) | 4.64(4.68) | <0.0001 | 1.35(2.05) | 4.29(4.11) | <0.0001 | 1.00(1.67) | 4.17(4.08) | <0.0001 | 0.64(1.32) | 4.24(4.13) | <0.0001 |
Outpatient ER Visits | 0.04(0.22) | 0.17(0.45) | <0.0001 | 0.02(0.16) | 0.20(0.47) | <0.0001 | 0.02(0.14) | 0.25(0.51) | <0.0001 | 0.01(0.12) | 0.29(0.53) | <0.0001 |
Outpatient Pharmacy Visits | 1.76(1.93) | 2.29(2.16) | <0.0001 | 1.43(1.60) | 2.34(1.96) | <0.0001 | 1.21(1.40) | 2.28(1.76) | <0.0001 | 0.47(0.93) | 1.74(1.50) | <0.0001 |
Outpatient Office Visits | 1.00(1.50) | 1.42(1.49) | <0.0001 | 0.77(1.31) | 1.50(1.41) | <0.0001 | 0.62(1.19) | 1.38(1.35) | <.0001 | 0.41(0.98) | 1.39(1.34) | <0.0001 |
All-cause Healthcare Utilizations 1 year (31–365 days) post-index date | ||||||||||||
Number of continuous enrollment patients | 8447[78.6 %] | 7808[72.7 %] | <0.0001 | 75203[83.0 %] | 70525[77.8 %] | <0.0001 | 6588[83.0 %] | 6165[77.7 %] | <.0001 | 10806[86.3 %] | 10089[80.5 %] | <0.0001 |
Inpatient LOS (days) | 2.06(13.01) | 6.61(20.85) | <0.0001 | 0.70(4.94) | 3.20(13.27) | <0.0001 | 0.51(3.98) | 2.46(11.26) | <.0001 | 0.23(2.72) | 1.75(10.73) | <0.0001 |
Number of patients with Inpatient Visits | 1304[15.4 %] | 2916[37.3 %] | <0.0001 | 6442[8.6 %] | 18316[26.0 %] | <0.0001 | 445[6.8 %] | 1439[23.3 %] | <.0001 | 376[3.5 %] | 1747[17.3 %] | <0.0001 |
Number of patients with Outpatient ER Visits | 2062[24.4 %] | 2767[35.4 %] | <0.0001 | 11284[15.0 %] | 19597[27.8 %] | <0.0001 | 876[13.3 %] | 1558[25.3 %] | <.0001 | 1109[10.3 %] | 2370[23.5 %] | <0.0001 |
Number of patients with Outpatient Office Visits | 7810[92.5 %] | 7423[95.1 %] | <0.0001 | 70005[93.1 %] | 68022[96.5 %] | <0.0001 | 5692[86.4 %] | 5801[94.1 %] | <.0001 | 8009[74.1 %] | 9396[93.1 %] | <0.0001 |
Number of patients with Outpatient Visitsb | 8216[97.3 %] | 7726[98.9 %] | <0.0001 | 72302[96.1 %] | 69833[99.0 %] | <0.0001 | 6028[91.5 %] | 6048[98.1 %] | <.0001 | 8569[79.3 %] | 9777[96.9 %] | <0.0001 |
Number of patients with Outpatient Pharmacy Visits | 6685[79.1 %] | 6397[81.9 %] | <0.0001 | 61668[82.0 %] | 59379[84.2 %] | <0.0001 | 5440[82.6 %] | 5411[87.8 %] | <.0001 | 6611[61.2 %] | 8281[82.1 %] | <0.0001 |
Number of visits PPPM | ||||||||||||
Inpatient stays | 0.02(0.06) | 0.06(0.11) | <0.0001 | 0.01(0.04) | 0.04(0.09) | <0.0001 | 0.01(0.03) | 0.03(0.07) | <.0001 | 0.00(0.02) | 0.02(0.06) | <0.0001 |
OutpatientVisitsb | 1.81(1.71) | 2.62(2.20) | <0.0001 | 1.28(1.33) | 2.13(1.86) | <0.0001 | 0.95(1.09) | 1.74(1.62) | <.0001 | 0.65(0.88) | 1.50(1.47) | <0.0001 |
Outpatient ER Visits | 0.04(0.08) | 0.06(0.14) | <0.0001 | 0.02(0.06) | 0.04(0.10) | <0.0001 | 0.02(0.05) | 0.04(0.09) | <.0001 | 0.01(0.04) | 0.03(0.08) | <0.0001 |
Outpatient Pharmacy Visits | 1.66(1.53) | 2.05(1.69) | <0.0001 | 1.37(1.28) | 1.87(1.48) | <0.0001 | 1.18(1.12) | 1.80(1.32) | <.0001 | 0.50(0.75) | 1.29(1.11) | <0.0001 |
Outpatient Office Visits | 0.90(0.88) | 1.10(0.99) | <0.0001 | 0.73(0.79) | 0.98(0.87) | <0.0001 | 0.57(0.71) | 0.80(0.80) | <0.0001 | 0.42(0.64) | 0.68(0.73) | <0.0001 |
All-cause healthcare utilization 2 years post-index date | ||||||||||||
Number of patients with Inpatient Visits | 848[14.3 %] | 1660[29.8 %] | <0.0001 | 5208[8.8 %] | 11020[20.7 %] | <0.0001 | 394[7.7 %] | 856[18.4 %] | <0.0001 | 391[4.4 %] | 915[11.7 %] | <0.0001 |
Number of patients with Outpatient ER Visits | 1455[24.5 %] | 1845[33.1 %] | <0.0001 | 9514[16.1 %] | 13799[25.9 %] | <0.0001 | 759[14.9 %] | 1134[24.3 %] | <0.0001 | 963[10.9 %] | 1583[20.2 %] | <0.0001 |
Number of patients with Outpatient Office Visits | 5371[90.6 %] | 5084[91.2 %] | 0.286 | 54074[91.8 %] | 49751[93.5 %] | <0.0001 | 4433[87.0 %] | 4213[90.4 %] | <0.0001 | 6969[78.8 %] | 6944[88.8 %] | <0.0001 |
Number of patients with Outpatient Visitsb | 5668[95.6 %] | 5352[96.0 %] | 0.325 | 55882[94.9 %] | 51394[96.6 %] | <0.0001 | 4669[91.6 %] | 4445[95.3 %] | <0.0001 | 7377[83.4 %] | 7286[93.1 %] | <0.0001 |
Number of patients with Outpatient Pharmacy Visits | 4720[79.6 %] | 4549[81.6 %] | 0.008 | 48323[82.0 %] | 44590[83.8 %] | <0.0001 | 4228[83.0 %] | 4015[86.1 %] | <0.0001 | 5886[66.6 %] | 6324[80.8 %] | <0.0001 |
All-cause healthcare utilization 3 years post-index date | ||||||||||||
Number of patients with Inpatient Visits | 563[14.1 %] | 961[27.2 %] | <0.0001 | 3941[8.8 %] | 7146[18.6 %] | <0.0001 | 288[7.4 %] | 590[16.9 %] | <0.0001 | 325[4.5 %] | 617[10.3 %] | <0.0001 |
Number of patients with Outpatient ER Visits | 965[24.2 %] | 1173[33.2 %] | <0.0001 | 7049[15.8 %] | 9683[25.2 %] | <0.0001 | 503[12.9 %] | 817[23.4 %] | <0.0001 | 804[11.2 %] | 1187[19.9 %] | <0.0001 |
Number of patients with Outpatient Office Visits | 3569[89.4 %] | 3150[89.2 %] | 0.78 | 40638[91.0 %] | 35419[92.0 %] | <0.0001 | 3420[87.6 %] | 3095[88.8 %] | 0.115 | 5871[81.7 %] | 5209[87.2 %] | <0.0001 |
Number of patients with Outpatient Visitsb | 3775[94.5 %] | 3335[94.4 %] | 0.819 | 42139[94.4 %] | 36762[95.5 %] | <0.0001 | 3587[91.9 %] | 3272[93.9 %] | 0.001 | 6194[86.2 %] | 5468[91.6 %] | <0.0001 |
Number of patients with Outpatient Pharmacy Visits | 3216[80.5 %] | 2908[82.3 %] | 0.047 | 36437[81.6 %] | 32319[84.0 %] | <0.0001 | 3221[82.5 %] | 2958[84.9 %] | 0.006 | 4991[69.4 %] | 4804[80.5 %] | <0.0001 |