| |
History of CV event cohort
|
Modified CHD RE Cohort
|
Moderate risk cohort
|
Low risk cohort
|
|---|
|
Without CV events
|
With CV events
| |
Without CV events
|
With CV events
| |
Without CV events
|
With CV events
| |
Without CV events
|
With CV events
| |
|---|
|
(N = 10741)
|
(N = 10741)
|
(N = 90614)
|
(N = 90614)
|
(N = 7938)
|
(N = 7938)
|
(N = 12527)
|
(N = 12527)
|
|---|
|
Mean [%]/(SD)
|
Mean [%]/(SD)
|
P-valuea
|
STD
|
Mean [%]/(SD)
|
Mean [%]/(SD)
|
P-Valuea
|
STD
|
Mean [%]/(SD)
|
Mean [%]/(SD)
|
P-valuea
|
STD
|
Mean [%]/(SD)
|
Mean [%]/(SD)
|
P-valuea
|
STD
|
|---|
|
Age
|
73.66(13.15)
|
71.76(12.18)
|
<0.0001
| |
65.32(12.95)
|
64.69(12.75)
|
<0.0001
| |
65.58(11.93)
|
65.45(12.11)
|
0.503
| |
56.18(11.24)
|
55.86(10.92)
|
0.022
| |
|
18–24
|
[0.0 %]
|
[0.0 %]
|
N/A
|
0.0
|
[0.0 %]
|
[0.0 %]
|
0.336
|
0.5
|
[0.0 %]
|
[0.0 %]
|
N/A
|
0.0
|
[0.1 %]
|
[0.1 %]
|
0.683
|
0.5
|
|
25–34
|
[0.1 %]
|
[0.1 %]
|
0.781
|
0.4
|
[0.3 %]
|
[0.3 %]
|
0.189
|
0.6
|
[0.0 %]
|
[0.0 %]
|
N/A
|
0.0
|
[1.1 %]
|
[1.1 %]
|
0.952
|
0.1
|
|
35–54
|
[7.0 %]
|
[6.0 %]
|
0.006
|
3.8
|
[19.0 %]
|
[19.7 %]
|
<0.0001
|
1.9
|
[14.6 %]
|
[14.5 %]
|
0.946
|
0.1
|
[45.6 %]
|
[45.6 %]
|
0.970
|
0.1
|
|
55–64
|
[22.1 %]
|
[20.9 %]
|
0.043
|
2.8
|
[36.7 %]
|
[36.4 %]
|
0.1
|
0.8
|
[43.9 %]
|
[43.8 %]
|
0.949
|
0.1
|
[36.9 %]
|
[36.9 %]
|
0.990
|
0.0
|
|
≥65
|
[70.9 %]
|
[73.0 %]
|
0.001
|
4.6
|
[44.0 %]
|
[43.6 %]
|
0.129
|
0.7
|
[41.6 %]
|
[41.7 %]
|
0.910
|
0.2
|
[16.3 %]
|
[16.3 %]
|
0.932
|
0.1
|
|
Male
|
[66.6 %]
|
[65.2 %]
|
0.029
|
3.0
|
[65.3 %]
|
[65.2 %]
|
0.657
|
0.2
|
[66.7 %]
|
[66.7 %]
|
0.946
|
0.1
|
[64.7 %]
|
[64.7 %]
|
0.926
|
0.1
|
|
US geographic region
| | | | | | | | | | | | | | | | |
|
Northeast
|
[39.3 %]
|
[39.5 %]
|
0.769
|
0.4
|
[35.5 %]
|
[35.3 %]
|
0.366
|
0.4
|
[32.1 %]
|
[32.1 %]
|
0.973
|
0.1
|
[35.2 %]
|
[35.3 %]
|
0.874
|
0.2
|
|
Midwest
|
[22.1 %]
|
[23.3 %]
|
0.040
|
2.8
|
[25.9 %]
|
[26.0 %]
|
0.351
|
0.4
|
[28.2 %]
|
[28.3 %]
|
0.930
|
0.1
|
[26.5 %]
|
[26.5 %]
|
0.989
|
0.0
|
|
South
|
[24.4 %]
|
[22.6 %]
|
0.002
|
4.3
|
[27.6 %]
|
[27.6 %]
|
0.992
|
0.0
|
[28.3 %]
|
[28.1 %]
|
0.874
|
0.3
|
[28.9 %]
|
[28.8 %]
|
0.933
|
0.1
|
|
West
|
[14.2 %]
|
[14.7 %]
|
0.351
|
1.3
|
[11.1 %]
|
[11.1 %]
|
0.929
|
0.0
|
[11.4 %]
|
[11.5 %]
|
0.960
|
0.1
|
[9.4 %]
|
[9.3 %]
|
0.914
|
0.1
|
|
Baseline comorbid condition
| | | | | | | | | | | | | | | | |
|
CCI Score
|
2.72(2.15)
|
2.82(2.14)
|
<0.001
|
4.9
|
1.23(1.54)
|
1.21(1.47)
|
<0.001
|
1.7
|
0.32(0.77)
|
0.31(0.75)
|
0.876
|
0.3
|
0.14(0.5)
|
0.14(0.49)
|
0.848
|
0.2
|
|
Chronic disease score
|
5.29(4.06)
|
5.49(4.19)
|
<0.001
|
5.0
|
4.58(3.62)
|
4.57(3.65)
|
0.716
|
0.2
|
3.99(2.86)
|
3.99(2.87)
|
0.892
|
0.2
|
0.97(1.74)
|
0.97(1.74)
|
0.957
|
0.1
|
|
Baseline number of inpatient visits PPPM
|
0.19(0.49)
|
0.2(0.45)
|
0.193
|
1.8
|
0.04(0.19)
|
0.04(018)
|
0.007
|
1.3
|
0.01(0.05)
|
0.01(0.05)
|
0.817
|
0.4
|
0(0.03)
|
0(0.03)
|
0.654
|
0.6
|
- Propensity score matching was applied for each cardiovascular disease risk cohort using covariates: age group, gender, US region, baseline Charlson comorbidity index score, Chronic Disease Score, comorbidities (hypertension, arrhythmias, metabolic syndrome, liver disease, obesity and chronic kidney disease) and number of inpatient admissions per patient per month.
- CHD RE coronary heart disease risk equivalent, SD standard deviation, STD standardized difference, CV cardiovascular, CVD cardiovascular disease, PPPM per patient per month, PSM propensity score matching
- aChi-square tests were used to evaluate the statistical significance of differences in categorical variables; student t-tests were used for the continuous variables
