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Table 1 PSM-adjusted 12-month pre-index demographic and clinical characteristics for hyperlipidemic patients with and without new CV events

From: Clinical and economic burden associated with cardiovascular events among patients with hyperlipidemia: a retrospective cohort study

  History of CV event cohort Modified CHD RE Cohort Moderate risk cohort Low risk cohort
Without CV events With CV events   Without CV events With CV events   Without CV events With CV events   Without CV events With CV events  
(N = 10741) (N = 10741) (N = 90614) (N = 90614) (N = 7938) (N = 7938) (N = 12527) (N = 12527)
Mean [%]/(SD) Mean [%]/(SD) P-valuea STD Mean [%]/(SD) Mean [%]/(SD) P-Valuea STD Mean [%]/(SD) Mean [%]/(SD) P-valuea STD Mean [%]/(SD) Mean [%]/(SD) P-valuea STD
Age 73.66(13.15) 71.76(12.18) <0.0001   65.32(12.95) 64.69(12.75) <0.0001   65.58(11.93) 65.45(12.11) 0.503   56.18(11.24) 55.86(10.92) 0.022  
18–24 [0.0 %] [0.0 %] N/A 0.0 [0.0 %] [0.0 %] 0.336 0.5 [0.0 %] [0.0 %] N/A 0.0 [0.1 %] [0.1 %] 0.683 0.5
25–34 [0.1 %] [0.1 %] 0.781 0.4 [0.3 %] [0.3 %] 0.189 0.6 [0.0 %] [0.0 %] N/A 0.0 [1.1 %] [1.1 %] 0.952 0.1
35–54 [7.0 %] [6.0 %] 0.006 3.8 [19.0 %] [19.7 %] <0.0001 1.9 [14.6 %] [14.5 %] 0.946 0.1 [45.6 %] [45.6 %] 0.970 0.1
55–64 [22.1 %] [20.9 %] 0.043 2.8 [36.7 %] [36.4 %] 0.1 0.8 [43.9 %] [43.8 %] 0.949 0.1 [36.9 %] [36.9 %] 0.990 0.0
≥65 [70.9 %] [73.0 %] 0.001 4.6 [44.0 %] [43.6 %] 0.129 0.7 [41.6 %] [41.7 %] 0.910 0.2 [16.3 %] [16.3 %] 0.932 0.1
Male [66.6 %] [65.2 %] 0.029 3.0 [65.3 %] [65.2 %] 0.657 0.2 [66.7 %] [66.7 %] 0.946 0.1 [64.7 %] [64.7 %] 0.926 0.1
US geographic region                 
Northeast [39.3 %] [39.5 %] 0.769 0.4 [35.5 %] [35.3 %] 0.366 0.4 [32.1 %] [32.1 %] 0.973 0.1 [35.2 %] [35.3 %] 0.874 0.2
Midwest [22.1 %] [23.3 %] 0.040 2.8 [25.9 %] [26.0 %] 0.351 0.4 [28.2 %] [28.3 %] 0.930 0.1 [26.5 %] [26.5 %] 0.989 0.0
South [24.4 %] [22.6 %] 0.002 4.3 [27.6 %] [27.6 %] 0.992 0.0 [28.3 %] [28.1 %] 0.874 0.3 [28.9 %] [28.8 %] 0.933 0.1
West [14.2 %] [14.7 %] 0.351 1.3 [11.1 %] [11.1 %] 0.929 0.0 [11.4 %] [11.5 %] 0.960 0.1 [9.4 %] [9.3 %] 0.914 0.1
Baseline comorbid condition                 
CCI Score 2.72(2.15) 2.82(2.14) <0.001 4.9 1.23(1.54) 1.21(1.47) <0.001 1.7 0.32(0.77) 0.31(0.75) 0.876 0.3 0.14(0.5) 0.14(0.49) 0.848 0.2
Chronic disease score 5.29(4.06) 5.49(4.19) <0.001 5.0 4.58(3.62) 4.57(3.65) 0.716 0.2 3.99(2.86) 3.99(2.87) 0.892 0.2 0.97(1.74) 0.97(1.74) 0.957 0.1
Baseline number of inpatient visits PPPM 0.19(0.49) 0.2(0.45) 0.193 1.8 0.04(0.19) 0.04(018) 0.007 1.3 0.01(0.05) 0.01(0.05) 0.817 0.4 0(0.03) 0(0.03) 0.654 0.6
  1. Propensity score matching was applied for each cardiovascular disease risk cohort using covariates: age group, gender, US region, baseline Charlson comorbidity index score, Chronic Disease Score, comorbidities (hypertension, arrhythmias, metabolic syndrome, liver disease, obesity and chronic kidney disease) and number of inpatient admissions per patient per month.
  2. CHD RE coronary heart disease risk equivalent, SD standard deviation, STD standardized difference, CV cardiovascular, CVD cardiovascular disease, PPPM per patient per month, PSM propensity score matching
  3. aChi-square tests were used to evaluate the statistical significance of differences in categorical variables; student t-tests were used for the continuous variables