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Table 3 Risk of AMI in rosiglitazone users compared with pioglitazone users, overall and subgroup analyses

From: Cardiovascular risk associated with the use of glitazones, metformin and sufonylureas: meta-analysis of published observational studies

Study (author, year) Overall RR (95 % CI) Subgroup analyses
  Overall sensitivity analysisa Incident and prevalent cases New users
     Sensitivity analysisa   Sensitivity analysisa
Walker, 2008 [39] 0.82 (0.49–1.37)      
Ziyadeh, 2009 [42] 1.35 (1.12–1.62)      
Brownstein, 2010 [27] 1.70 (1.31–2.21) Not included   Not included Not reported Not reported
Bilik, 2010 [26] 0.75 (0.33–1.67)     Not reported Not reported
Wertz, 2010 [40] 0.92 (0.70–1.20)      
Dormuth, 2009 [28] 1.00 (0.67–1.49)      
Juurlink, 2009 [33] 1.05 (0.90–1.23)      
Graham, 2010 [30] 1.06 (0.96–1.18)      
Winkelmayer, 2008 [41] 1.08 (0.93–1.25)   Not reported    
Koro, 2008 [34] 1.12 (0.99–1.26)   Not reported   Not reported Not reported
Gerrits, 2007 [29] 1.27 (1.06–1.52) Not included   Not included   Not included
Fixed-effects, sRR (95 % CI) 1.12 (1.06–1.18) 1.09 (1.03–1.15) 1.13 (1.06–1.21) 1.08 (1.00–1.16) 1.10 (1.03–1.17) 1.08 (1.01–1.15)
Random-effects, sRR (95 % CI) 1.13 (1.04–1.24) 1.09 (1.02–1.16) 1.14 (1.00–1.30) 1.07 (0.96–1.19) 1.10 (1.01–1.20) 1.08 (0.99–1.18)
Heterogeneity statistics τ2 = 0.01
χ2 = 22.05, df = 10 (P = 0.01)
I 2 = 55 %
τ2 = 0.00
χ2 = 9.56, df = 8
(P = 0.30)
I 2 = 16 %
τ2 = 0.02
χ2 = 21.74, df = 8 (P = 0.005)
I 2 = 63 %
τ2 = 0.01
χ2 = 9.26, df = 6 (P = 0.16)
I 2 = 35 %
τ2 = 0.01
χ2 = 11.06, df = 7 (P = 0.14)
I 2 = 37 %
τ2 = 0.00
χ2 = 8.47, df = 6 (P = 0.21)
I 2 = 29 %
  1. Not reported indicates that the study did not provide an estimate for that subgroup analysis. Not included indicates that the study was removed as part of the sensitivity analysis
  2. df degrees of freedom, RR relative risk, sRR summary relative risk
  3. aSensitivity analysis: we excluded those studies with a combined high or unclear risk of bias for more than 30 % of the items in the RTI item bank