Table 4 Uni- and multivariable predictors of outcome

 Age (year)

1.10

1.07–1.14

<0.001

1.09

1.05–1.12

<0.001

 Dyspnea ≥3

2.29

1.77–2.97

<0.001

1.81

1.37–2.39

<0.001

 CIRS (per point increase)

1.21

1.12–1.30

<0.001

1.11

1.03–1.21

0.007

 Moderate-to-severe VHD

1.91

1.42–2.58

<0.001

1.42

1.04–1.95

0.029

 Moderate-to-severe AS

1.96

1.42–2.70

<0.001

 LAVI ≥34 mL/m²

1.58

1.22–2.04

0.001

 LV hypertrophy

1.01

1.00–1.01

0.004

1.01

1.00–1.01

0.020

 Moderate-to-severe MS

2.30

1.08–4.88

0.030

 LVEF ≤50 %

1.63

1.02–2.61

0.040

1.66

1.03–2.67

0.037

 Dyslipidemia

0.78

0.60–1.01

0.063

 Age (year)

1.09

1.04–1.14

<0.001

1.06

1.01–1.11

0.014

 CIRS (per point increase)

1.23

1.10–1.37

<0.001

 Dyspnea ≥3

3.06

2.07–4.53

<0.001

2.68

1.80–3.98

<0.001

 Moderate-to-severe VHD

2.88

1.90–4.37

<0.001

2.13

1.38–3.29

0.001

 Moderate-to-severe AS

3.06

1.99–4.72

<0.001

 Moderate-to-severe MS

4.65

2.03–10.63

<0.001

 LAVI ≥34 mL/m²

1.87

1.27–2.77

0.002

 LV hypertrophy

1.01

1.00–1.02

0.029

1.01

1.00–1.01

0.087

 Smoker (current or ex)

1.60

1.25–2.04

<0.001

1.69

1.32–2.16

<0.001

 CIRS (per point increase)

1.20

1.13–1.29

<0.001

1.15

1.07–1.23

<0.001

 Dyspnea ≥3

1.81

1.42–2.31

<0.001

1.50

1.16–1.94

0.002

 Moderate-to-severe AS

1.71

1.25–2.33

0.001

 LAVI ≥34 mL/m²

1.37

1.08–1.74

0.009

 Moderate-to-severe VHD

1.51

1.13–2.03

0.006

1.43

1.06–1.94

0.021

 Age (year)

1.03

1.00–1.06

0.041