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Table 4 Uni- and multivariable predictors of outcome

From: The clinical impact of valvular heart disease in a population-based cohort of subjects aged 80 and older

  Univariable Multivariable
  HR 95 % CI p value HR 95 % CI p value
All-cause mortality
 Age (year) 1.10 1.07–1.14 <0.001 1.09 1.05–1.12 <0.001
 Dyspnea ≥3 2.29 1.77–2.97 <0.001 1.81 1.37–2.39 <0.001
 CIRS (per point increase) 1.21 1.12–1.30 <0.001 1.11 1.03–1.21 0.007
 Moderate-to-severe VHD 1.91 1.42–2.58 <0.001 1.42 1.04–1.95 0.029
 Moderate-to-severe AS 1.96 1.42–2.70 <0.001    
 LAVI ≥34 mL/m2 1.58 1.22–2.04 0.001    
 LV hypertrophy 1.01 1.00–1.01 0.004 1.01 1.00–1.01 0.020
 Moderate-to-severe MS 2.30 1.08–4.88 0.030    
 LVEF ≤50 % 1.63 1.02–2.61 0.040 1.66 1.03–2.67 0.037
 Dyslipidemia 0.78 0.60–1.01 0.063    
Cardiovascular mortality
 Age (year) 1.09 1.04–1.14 <0.001 1.06 1.01–1.11 0.014
 CIRS (per point increase) 1.23 1.10–1.37 <0.001    
 Dyspnea ≥3 3.06 2.07–4.53 <0.001 2.68 1.80–3.98 <0.001
 Moderate-to-severe VHD 2.88 1.90–4.37 <0.001 2.13 1.38–3.29 0.001
 Moderate-to-severe AS 3.06 1.99–4.72 <0.001    
 Moderate-to-severe MS 4.65 2.03–10.63 <0.001    
 LAVI ≥34 mL/m2 1.87 1.27–2.77 0.002    
 LV hypertrophy 1.01 1.00–1.02 0.029 1.01 1.00–1.01 0.087
First unplanned Hospitalization
 Smoker (current or ex) 1.60 1.25–2.04 <0.001 1.69 1.32–2.16 <0.001
 CIRS (per point increase) 1.20 1.13–1.29 <0.001 1.15 1.07–1.23 <0.001
 Dyspnea ≥3 1.81 1.42–2.31 <0.001 1.50 1.16–1.94 0.002
 Moderate-to-severe AS 1.71 1.25–2.33 0.001    
 LAVI ≥34 mL/m2 1.37 1.08–1.74 0.009    
 Moderate-to-severe VHD 1.51 1.13–2.03 0.006 1.43 1.06–1.94 0.021
 Age (year) 1.03 1.00–1.06 0.041    
  1. AS aortic stenosis, CI confidence interval, CIRS cumulative illness rating scale, HR hazard ratio, LAVI left atrial volume index, LVEF left ventricular ejection fraction, MS mitral stenosis, VHD valvular heart disease