Table 3 Baseline characteristics according to diastolic function. Similar variables, obtained at follow-up, are depicted for comparison
Variable | All subjects (n = 227) | Normal or grade 1 diastolic dysfunction (n = 145) | Grade 2 or 3 diastolic dysfunction (n = 82) | P-value for difference between diastolic dysfunction categories |
|---|---|---|---|---|
MPP baseline | ||||
Age (years) | 47 [47–48] | 47 [47–48] | 47 [47–48] | 0.5c |
Active smoking | 109 (48 %) | 73 (50 %) | 36 (44 %) | 0.4a |
BMI (kg/m2) | 25.1 +/− 3.1 | 24.7 +/− 3.0 | 25.9 +/− 3.1 | 0.003b |
Systolic blood pressure (mmHg) | 129 +/− 15 | 129 +/− 16 | 129 +/− 15 | 0.7b |
Total cholesterol (mmol/L) | 5.7 +/− 1.0 | 5.7 +/− 0.9 | 5.7 +/− 1.2 | 0.8b |
Creatinine (μmol/L) | 92 +/− 13 | 91 +/− 12 | 94 +/− 14 | 0.09b |
FBG (mmol/L) | 5.1 +/− 0.5 | 5.1 +/− 0.5 | 5.1 +/− 0.5 | 0.6b |
Fasting insulin (pmol/L) | 48 [38–84] | 42 [18–72] | 54 [18–84] | 0.1c |
HOMA-%B | 100.3 [68.7–137.9] | 77.7 [52.0–117.6] | 92.5 [58.0–133.6] | 0.2c |
HOMA-%S | 111.0 [64.1–138.4] | 124.4 [75.9–286.5] | 99.6 [62.8–279.7] | 0.1c |
Sedentary lifestyle | 133 (59 %) | 86 (59 %) | 47 (57 %) | 0.8a |
Antihypertensive medication | 10 (4 %) | 6 (4 %) | 4 (5 %) | 0.8a |
MPP re-examination | ||||
Age (years) | 74 [70–75] | 74 [71–75] | 74 [70–75] | 0.5c |
Active smoking | 32 (14 %) | 22 (15 %) | 10 (12 %) | 0.5a |
BMI (kg/m2) | 27.9 +/− 3.5 | 27.4 +/− 3.3 | 28.9 +/− 3.7 | 0.002b |
Systolic blood pressure (mmHg) | 148 +/− 20 | 147 +/− 20 | 151 +/− 21 | 0.2b |
Total cholesterol (mmol/L) | 5.1 +/− 1.1 | 5.1 +/− 1.1 | 4.9 +/− 1.0 | 0.2b |
FPG (mmol/L) | 7.1 +/− 2.1 | 7.0 +/− 2.0 | 7.2 +/− 2.2 | 0.5b |
LVM (g) | 202 +/− 63 | 197 +/− 64 | 212 +/− 58 | 0.1b |
LVMI (g/m2) | 103 +/− 31 | 101 +/− 32 | 106 +/− 28 | 0.2b |
EF (%) | 60 +/− 9 | 60 +/− 8 | 62 +/− 10 | 0.09b |
E/é | 10 [7–12] | 8 [7–10] | 13 [12–15] | <0.0001c |
Time (years) | 28 [28–29] | 28 [27–29] | 28 [25–28] | 0.02c |