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Fig. 2 | BMC Cardiovascular Disorders

Fig. 2

From: Administration of granulocyte-colony stimulating factor accompanied with a balanced diet improves cardiac function alterations induced by high fat diet in mice

Fig. 2

Body weight and biochemical analysis. a Body weight was measured from the beginning (T0) until the completion of HFD (36 weeks), in 4-week intervals. Following the completion of the HFD-induced DM2, mice returned to standard diet where some animals received G-CSF or saline treatment until 52 weeks. (Values are expressed as mean ± SEM. HFD mice vs. standard diet mice ***p < 0.001; G-CSF-treated mice vs. standard diet fed mice ‡p < 0.01; Saline-treated mice vs standard diet fed mice †p < 0.001; Saline-treated mice vs standard diet fed mice ††p < 0.001). (b) Glycemia was measured from the beginning (T0) until the completion of HFD (36 weeks), in 4-week intervals. Following the completion of the HFD-induced DM2, mice returned to standard diet where some animals received G-CSF or saline treatment until 52 weeks. (Values are expressed as mean ± SEM. HFD mice vs. standard diet mice, *p < 0.05, **p < 0.01, ***p < 0.001). c Cholesterol was measured before (T0), at the end of HFD consumption (36 weeks) and following G-CSF/saline administration (52 weeks) (Values are expressed as mean ± SEM. HFD mice vs. standard diet mice, **p < 0.01; G-CSF-treated mice T0 vs. T36, ††p < 0.01). d Plasma insulin concentrations were evaluated at 36 and 52 weeks. (Values are expressed as mean ± SEM. G-CSF-treated mice vs. standard diet mice *p < 0.05; Saline-treated mice vs standard diet mice, ††p < 0.001; HFD-Saline vs. HFD-G-CSF, #p < 0.05)

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