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Table 1 Baseline characteristics of adult residents with and without incident CHD during follow-up in the Vara-Skövde cohort

From: Circulating concentrations of endothelin-1 predict coronary heart disease in women but not in men: a longitudinal observational study in the Vara-Skövde Cohort

 

Men

Women

 

All N = 1350

No CHD N = 1298

CHD N = 52

P-value

All N = 1395

No CHD N = 1375

CHD N = 20

P-value

 

Mean ± SD

 

Mean ± SD

 

Age (yrs)

47.3±11

46.7 ± 11

61.2±11

<0.001

47.7±12

47.4±12

63.9±11

<0.001

WHR

0.9±0.1

0.9±0.1

1.0±0.1

<0.001

0.8±0.1

0.8±0.1

0.9±0.1

0.004

BMI (kg/m2)

26.9±4

26.8±4

27.4±3

0.200

26.8±5

26.8±5

27.8±4

0.661

HOMA-IR

1.6±1.3

1.6±1.3

2.4±1.8

<0.001

1.5±1.6

1.5±1.6

2.1±1.7

0.073

S-LDL (mmol/l)

3.4 ± 0.9

3.4 ± 0.9

3.9 ± 0.9

<0.001

3.2 ± 0.9

3.1 ± 0.9

3.8 ± 1.1

0.001

S-HDL (mmol/l)

1.2 ± 0.3

1.2 ± 0.3

1.2 ± 0.3

0.916

1.4 ± 0.3

1.4 ± 0.3

1.3 ± 0.4

0.164

S-Cholesterol (mmol/l)

5.4 ± 1

5.4 ± 1

5.7 ± 1

0.018

5.3 ± 1.1

5.2 ± 1

5.4 ± 1.2

0.331

ApoB/apoA1

0.6 ± 0.2

0.6 ± 0.2

0.7 ± 0.2

0.002

0.5 ± 0.2

0.6 ± 0.2

0.7 ± 0.2

0.021

S-Triglycerides (mmol/l)

1.5 ± 0.9

1.4 ± 0.9

1.8 ± 1.1

0.018

1.1 ± 0.6

1.1 ± 0.6

1.4 ± 0.9

0.003

Hs-CRP (mg/l)

2.4 ± 5.8

2.2 ± 4.2

6.1 ± 21

<0.001

2.8 ± 4.6

2.8 ± 4.6

3.2 ± 3.9

0.675

Systolic blood pressure (mmHg)

124 ± 16

123 ± 15

138 ± 19

<0.001

119 ± 18

119 ± 18

143 ± 20

<0.001

Diastolic blood pressure (mmHg)

72 ± 10

72 ± 10

78 ± 12

<0.001

69 ± 10

68 ± 10

77 ± 10

<0.001

Alcohol consumption (g/week)

62 ± 108

62 ± 108

55 ± 91

0.666

31 ± 43

31 ± 44

20 ± 36

0.278

S-Testosterone (nmol/l)

14 ± 4.3

14 ± 4.3

13 ± 4.7

0.147

1.3 ± 1.3

1.3 ± 1.3

1.1 ± 0.5

0.524

S-Estradiol (nmol/l)

125 ± 37

125 ± 37

126 ± 40

0.875

304±381

305 ± 383

221 ± 50

0.314

 

N (%)

 

N (%)

 

Hypertension

183 (14)

165 (13)

22 (42)

<0.001

204 (14)

192 (14)

12 (57)

<0.001

Type 2 diabetes

78 (5.7)

66 (5)

12 (23)

<0.001

65 (4.6)

61 (4.4)

4 (19)

0.004

Daily smoking

214 (16)

201 (15)

13 (25)

0.068

288 (21)

282 (20)

6 (29)

0.364

Low physical activity

521 (38)

500 (40)

21 (45)

0.742

384 (27)

382 (29)

2 (10)

0.088

Medication

        

ARB

14 (1.0)

13 (1.0)

1 (1.9)

0.886

13 (0.9)

13 (1.0)

0 (0)

0.999

ASA

31 (2.2)

27 (2.1)

4 (7.7)

0.991

34 (2.4)

31 (2.2)

3 (14)

0.426

Statin

25 (1.8)

22 (1.7)

3 (5.8)

0.673

42 (2.9)

38 (2.7)

4 (19)

0.247

β-Blocker

64 (4.7)

58 (4.4)

6 (11.5)

0.830

89 (6.3)

80 (5.8)

9 (43)

0.007

ACE inhibitor

24 (1.8)

21 (1.6)

3 (5.8)

0.716

29 (2)

26 (1.9)

3 (14)

0.166

Metformin

14 (1.0)

13 (1.0)

1 (1.9)

0.992

19 (1.3)

18 (1.3)

1 (4.8)

0.988

HRT

-

-

-

-

247 (17)

238 (17)

9 (43)

0.434

  1. All means are adjusted
  2. All means are adjusted for differences in age. CHD: coronary heart disease; WHR: waist hip ratio (missing 10/2745); BMI: body mass index (missing 3/2745); HOMA-IR: homeostatic model assessment of insulin resistance (missing 39/2745); LDL: low-density lipoprotein (missing 2/2745); HDL: high-density lipoprotein (missing 2/2745); ApoB/apoA1: apolipoprotein B/apolipoprotein A1 (missing 4/2745), hs-CRP: high sensitivity c-reactive protein (missing 2/2745); testosterone (missing 135/2745); estradiol (missing 30/2745); type 2 diabetes (missing 2/2745); physical activity (missing 91/2745); ARB: angiotensin II receptor blockers; ASA: acetyl-salicylic acid; ACE inhibitors: angiotensin converting enzyme inhibitor; HRT: hormone replacement therapy. 12 g alcohol is equivalent to approximately 1 glass of wine (12–15 cl) or 1 small beer (33 cl) (missing 126/2745). Differences in continuous variables were investigated using general linear models. Differences in dichotomous variables were analysed using logistic regression analyses
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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