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Table 2 Dose adjustment of dabigatran, rivaroxaban and apixaban according to age, renal function and body weight

From: Antithrombotic treatment in elderly patients with atrial fibrillation: a practical approach

Drug Age Renal function Body weight
Dabigatran • <75 years: 150 mg b.i.d. • CrCl ≥50 mL/min: no dose adjustment is necessary. • No dose adjustment is necessary according to body weight. However, close clinical follow-up is required for patients with a body weight <50 kg.
• 75-80 years: 150 b.i.d. (110 mg b.i.d. should be considered when the risk of stroke is low and the bleeding risk is high). • CrCl 30-50 mL/min: the recommended dose is 150 mg b.i.d. (110 mg b.i.d. for patients with high risk of bleeding).
• ≥80 years: 110 mg b.i.d. • CrCl < 30 ml/min: contraindicated.
Rivaroxaban • No dose adjustment is required. • CrCl ≥50 mL/min: 20 mg o.d. • No dose adjustment is necessary according to body weight.
• CrCl 15-49 mL/min: 15 mg o.d.
• CrCl <15 mL/min: not recommended.
Apixaban • Recommended dose: 5 mg b.i.d. • Recommended dose: 5 mg b.i.d. • Recommended dose: 5 mg b.i.d.
• 2.5 mg b.i.d. in case of at least 2 of the following characteristics: age ≥80 years, body weight ≤60 kg, or serum creatinine ≥ 1.5 mg/dL. • 2.5 mg b.i.d. in case of at least 2 of the following characteristics: age ≥80 years, body weight ≤60 kg, or serum creatinine ≥ 1.5 mg/dL. • 2.5 mg b.i.d. in case of at least 2 of the following characteristics: age ≥80 years, body weight ≤60 kg, or serum creatinine ≥ 1.5 mg/dL.
• No dose adjustment is required according to age, unless criteria for dose reduction are met. • No dose adjustment is necessary in patients with mild or moderate renal impairment, unless criteria for dose reduction are met. • No dose adjustment is required according to body weight, unless criteria for dose reduction are met
• CrCl 15-29 mL/min: 2.5 mg b.i.d.
• CrCl < 15 ml/min, or dialysis: not recommended.
Edoxaban • No dose adjustment is required. • CrCl ≥50 mL/min: 60 mg o.d. • Body weight >60 kg: 60 mg o.d.
• CrCl 15-49 mL/min: 30 mg o.d. • Body weight ≤60 kg: 30 mg o.d.
• CrCl <15 mL/min: not recommended.
  1. CrCl creatinine clearance, b.i.d. twice daily, o.d. once daily
  2. Data taken from references #104-107