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Fig. 4 | BMC Cardiovascular Disorders

Fig. 4

From: Left ventricular diastolic dysfunction in nonhuman primate model of dysmetabolism and diabetes

Fig. 4

H&E staining from 2 representative diabetic monkeys with left ventricular diastolic dysfunction (Amplification: 20X for the original and 40X for corner image). a & b: A 23 year old female monkey with hyperglycemia (FBG: 429 mg/mL, HbA1c: 10.4 %), significantly reduced E/A (0.64) as well as increased E DT (144 ms) and LADmax (1.76 cm). a Focal myocardial inflammation: Inflammatory cell infiltration around the small vascular and light myocardial cell edema (indicated by ➡). b Broken myocardial muscle fibers with increased eosinophils (indicated by ➡). c A 21 years old male monkey with hyperglycemia (FBG: 247 mg/mL, HbA1c: 11.2 %), significantly reduced E/A (1.01) as well as increased E DT (159 ms) and LADmax (1.31 cm). Sings of myocardial ischemia and cardiac muscle atrophy: Accumulation of brown granules at the nuclear poles of the cardiac muscle fiber cytoplasm (indicated by ➡)

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