Fig. 4From: Left ventricular diastolic dysfunction in nonhuman primate model of dysmetabolism and diabetesH&E staining from 2 representative diabetic monkeys with left ventricular diastolic dysfunction (Amplification: 20X for the original and 40X for corner image). a & b: A 23Â year old female monkey with hyperglycemia (FBG: 429Â mg/mL, HbA1c: 10.4Â %), significantly reduced E/A (0.64) as well as increased E DT (144Â ms) and LADmax (1.76Â cm). a Focal myocardial inflammation: Inflammatory cell infiltration around the small vascular and light myocardial cell edema (indicated by âž¡). b Broken myocardial muscle fibers with increased eosinophils (indicated by âž¡). c A 21Â years old male monkey with hyperglycemia (FBG: 247Â mg/mL, HbA1c: 11.2Â %), significantly reduced E/A (1.01) as well as increased E DT (159Â ms) and LADmax (1.31Â cm). Sings of myocardial ischemia and cardiac muscle atrophy: Accumulation of brown granules at the nuclear poles of the cardiac muscle fiber cytoplasm (indicated by âž¡)Back to article page