Protein/Receptor | Function |
---|---|
PAR | Induces release of nitric oxide and prostacyclin I2, activation of Weibel-Palade bodies, and expression of TF |
TF | Triggers the production of thrombin through activation of fX when in complex with fVIIa |
fVIII/fVIIIa | Amplifies the production of thrombin when in complex with fIXa |
VWF | Tethers platelets to collagen via glycoprotein VI on platelets |
Stabilizes fVIII in plasma | |
TFPI | Inhibits the activity of the TF/fVIIa complex and fXa |
Thrombomodulin | Eliminates the activity of thrombin when in complex |
Induces the activation of the protein C pathway | |
EPCR | Catalyzes conversion of Protein C to activated Protein C |
t-PA | Triggers fibrinolysis by converting plasminogen to plasmin |