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Table 2 Endothelial products in coagulation

From: Endothelial cell control of thrombosis

Protein/Receptor

Function

PAR

Induces release of nitric oxide and prostacyclin I2, activation of Weibel-Palade bodies, and expression of TF

TF

Triggers the production of thrombin through activation of fX when in complex with fVIIa

fVIII/fVIIIa

Amplifies the production of thrombin when in complex with fIXa

VWF

Tethers platelets to collagen via glycoprotein VI on platelets

Stabilizes fVIII in plasma

TFPI

Inhibits the activity of the TF/fVIIa complex and fXa

Thrombomodulin

Eliminates the activity of thrombin when in complex

Induces the activation of the protein C pathway

EPCR

Catalyzes conversion of Protein C to activated Protein C

t-PA

Triggers fibrinolysis by converting plasminogen to plasmin

  1. Abbreviations: EPCR endothelial protein C receptor, f factor, PAR protease-activated receptor, TF tissue factor, TFPI tissue factor pathway inhibitor, t-PA tissue-type plasminogen activator, VWF von Willebrand factor