Fig. 3
From: TSC-22 up-regulates collagen 3a1 gene expression in the rat heart
The effect of long-term treatment of heart failure and hypertension with metoprolol on transforming growth factor beta-stimulated clone 22 (TSC-22) expression. a Left ventricular (LV) TSC-22 mRNA levels measured by RT-PCR from rats 2 weeks after myocardial infarction (MI) and after metoprolol (METO) treatment post-MI (n = 7-8). ***P <0.001 versus sham. ƗP <0.001 versus MI (one-way ANOVA followed by least significance difference post hoc test). b LV TSC-22 mRNA levels from 12-month-old Wistar Kyoto (WKY) rats, untreated spontaneously hypertensive rats (SHR) and SHRs treated with metoprolol (METO) or losartan (Los) for 14 days (n = 5-6). *P <0.05 versus untreated SHR (one-way ANOVA followed by least significance difference post hoc test). The results are expressed as mean ± SEM