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Table 2 GEP variability performance results

From: Performance of gene-expression profiling test score variability to predict future clinical events in heart transplant recipients

Variability Score Scores ≤ Threshold % PPV % NPV % Sensitivity % Specificity %
(95 % CI) (95 % CI) (95 % CI) (95 % CI)
0.1 0.0 17.0 (−−) - 100.0 (90.3–100) 0.0 (0.0–6.5)
0.2 1.1 17.2 (11.6–23.8) 100.0 (−−) 100.0 (90.3–100) 1.8 (0.0–9.7)
0.3 3.3 17.8 (12.3–24.7) 100.0 (−−) 100.0 (90.3–100) 5.5 (1.1–15.1)
0.4 7.7 19.0 (13.1–26.9) 100.0 (−−) 100.0 (90.3–100) 12.7 (5.3–24.5)
0.5 16.5 22.0 (15.2–30.8) 100.0 (−−) 100.0 (90.3–100) 27.3 (16.1–41.0)
0.6 24.2 23.3 (15.7–33.0) 97.0 (91.4–100.0) 94.4 (81.3–99.3) 36.4 (23.8–50.4)
0.7 33.0 23.2 (15.4–33.7) 92.8 (85.4–97.8) 83.3 (67.2–93.6) 43.6 (30.3–57.7)
0.8 42.9 25.2 (16.3–37.1) 91.4 (84.2–96.5) 75.0 (57.8–87.9) 54.5 (40.6–68.0)
0.9 56.0 29.7 (18.5–46.0) 90.3 (83.9–95.2) 63.9 (46.2–79.2) 69.1 (55.2–80.9)
1.0 62.6 26.0 (14.8–41.8) 87.4 (80.1–92.9) 50.0 (32.9–67.1) 70.9 (57.1–82.4)
1.1 68.1 27.8 (15.3–46.5) 87.0 (80.4–92.4) 44.4 (27.9–61.9) 76.4 (63.0–86-8)
1.2 71.4 29.9 (16.3–51.0) 87.0 (80.3–92.2) 41.7 (25.5–59.2) 80.0 (67.0–89.6)
1.3 76.9 29.4 (14.6–53.4) 86.0 (79.3–91.3) 33.3 (18.6–51.0) 83.6 (71.2–92.2)
1.4 83.5 31.9 (13.5–63.2) 85.3 (78.7–90.6) 25.0 (12.1–42.2) 89.1 (77.8–95.9)
1.5 87.9 35.4 (13.5–75.8) 84.9 (78.5–90.1) 19.4 (8.2–36) 92.7 (82.4–98.0)
1.6 92.3 29.4 (5.9–100.0) 83.9 (77.1–89.4) 11.1 (3.1–26.1) 94.5 (84.9–98.9)
1.7 94.5 31.9 (0.0–100.0) 83.7 (77.1–89.1) 8.3 (1.8–22.5) 96.4 (87.5–99.6)
1.8 97.8 23.8 (−−) 83.2 (76.6–88.6) 2.8 (0.1–14.5) 98.2 (90.3–100.0)
1.9 98.9 100.0 (−−) 83.4 (77.0–88.7) 2.8 (0.1–14.5) 100.0 (93.5–100.0)
2.0 98.9 100.0 (−−) 83.4 (77.0–88.7) 2.8 (0.1–14.5) 100.0 (93.5–100.0)
2.1 100.0 --- (−−) 83.0 (76.6–88.4) 0.0 (0.0–9.7) 100.0 (93.5–100.0)
  1. CI confidence interval, GEP gene expression profiling, NPV negative predictive value, PPV positive predictive value